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Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis

  1. Author:
    Harman, F. S.
    Nicol, C. J.
    Marin, H. E.
    Ward, J. M.
    Gonzalez, F. J.
    Peters, J. M.

  2. Author Address

    Peters, JM, Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA. Penn State Univ, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA. Penn State Univ, Grad Program Biochem Microbiol & Mol Biol, University Pk, PA 16802 USA. NCI, Lab Metab, Bethesda, MD 20892 USA. NCI, Vet & Tumor Pathol Sect, Off Lab Anim Resources, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Nature Medicine
    1. 10
    2. 5
    3. Pages: 481-483
  4. Type of Article: Article
  1. Abstract:

    Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis

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