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Comparative pathology of nerve sheath tumors in mouse models and humans

  1. Author:
    Stemmer-Rachamimov, A. O.
    Louis, D. N.
    Nielsen, G. P.
    Antonescu, C. R.
    Borowsky, A. D.
    Bronson, R. T.
    Burns, D. K.
    Cervera, P.
    McLaughlin, M. E.
    Reifenberger, G.
    Schmale, M. C.
    MacCollin, M.
    Chao, R. C.
    Cichowski, K.
    Kalamarides, M.
    Messerli, S. M.
    McClatchey, A. I.
    Niwa-Kawakita, M.
    Ratner, N.
    Reilly, K. M.
    Zhu, Y.
    Giovannini, M.

  2. Author Address

    Giovannini, M, CEPH, Fdn Jean Dausset, INSERM, U434, 27 Rue Juliette Dodu, F-75010 Paris, France CEPH, Fdn Jean Dausset, INSERM, U434, F-75010 Paris, France. Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. Harvard Univ, Med Sch, Boston, MA 02114 USA. Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. Univ Calif Davis, Med Pathol Ctr Comparat Med, Davis, CA 95616 USA. Harvard Univ, Sch Med, Dept Pathol, Boston, MA USA. Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA. Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX USA. CEPH, Fdn Jean Dausset, INSERM, U434, Paris, France. Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. Univ Dusseldorf, Dept Neuropathol, Dusseldorf, Germany. Miami Univ, Rosenstiel Sch Marine & Atmospher Sci, Div Marine Biol & Fisheries, Miami, FL USA. Univ Calif San Francisco, Dept Med Vet Affairs, Ctr Med, Dept Med, San Francisco, CA 94143 USA. Harvard Univ, Sch Med, Boston, MA USA. Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA. Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp,Canc Ctr, Charlestown, MA USA. Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH USA. Mouse Canc Genet Program, Genet Modifiers Tumorigenesis Sect, NCI, Frederick, MD USA. Univ Michigan, Sch Med, Div Med & Mol Genet, Ann Arbor, MI USA.
    1. Year: 2004
  2. Journal: Cancer Research
    1. 64
    2. 10
    3. Pages: 3718-3724
  4. Type of Article: Article
  1. Abstract:

    Despite the progress made in our understanding of the biology of neurofibromatosis (NF), the long-term clinical outcome for affected patients has not changed significantly in the past decades, and both NF1 and NF2 are still associated with a significant morbidity and a decreased life span. A number of NF1 and NF2 murine models have been generated to aid in the study of NF tumor biology and in the development of targeted therapies for NF patients. A single, universal pathological classification of the lesions generated in these murine models is essential for the validation of the models, for their analysis and comparison with other models, and for their future effective use in preclinical treatment trials. For the formulation of a pathological classification of these lesions, the WHO classification of human tumors was used as a reference. However, it was not adopted for the classification of the GEM lesions because of some important differences between the human and murine lesions. A novel classification scheme for peripheral nerve sheath tumors in murine models was therefore devised

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External Sources

  1. View record in Web of Science®
  2. WOS: 000221419100050

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