Skip NavigationSkip to Content
Return Return to Search Results

Structural effects of radiation damage and its potential for phasing

  1. Author:
    Banumathi, S.
    Zwart, P. H.
    Ramagopal, U. A.
    Dauter, M.
    Dauter, Z.

  2. Author Address

    Dauter, Z, Brookhaven Natl Lab, Natl Canc Inst, MCL, Synchrotron Radiat Res Sect, Upton, NY 11973 USA Brookhaven Natl Lab, Natl Canc Inst, MCL, Synchrotron Radiat Res Sect, Upton, NY 11973 USA. Brookhaven Natl Lab, SAIC frederick Inc, Basic Res Program, Upton, NY 11973 USA.
    1. Year: 2004
  2. Journal: Acta Crystallographica Section D-Biological Crystallography
    1. 60
    2. Part 6
    3. Pages: 1085-1093
  4. Type of Article: Article
  1. Abstract:

    A detailed analysis of radiation-damage-induced structural and intensity changes is presented on the model protein thaumatin. Changes in reflection intensities induced by irradiation display a parabolic character. The most pronounced structural changes observed were disulfide-bond breakage and associated main-chain and side-chain movements as well as decarboxylation of aspartate and glutamate residues. The structural changes induced on the sulfur atoms were successfully used to obtain high-quality phase estimates via an RIP procedure. Results obtained with ACORN suggest that the contribution originating from the partial structure may play an important role in phasing even at less than atomic resolution

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel