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The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1

  1. Author:
    Daly, N. L.
    Gustafson, K. R.
    Craik, D. J.

  2. Author Address

    Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia. NCI, Mol Targets Dev Program, Canc Res Ctr, Frederick, MD 21702 USA Craik, DJ, Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
    1. Year: 2004
    2. Date: SEP 10
  2. Journal: Febs Letters
    1. 574
    2. 1-3
    3. Pages: 69-72
  4. Type of Article: Article
  1. Abstract:

    The plant cyclotides, the largest known family of circular proteins, have tightly folded structures and a range of biological activities that lend themselves to potential pharmaceutical and agricultural applications. Based on sequence homology, they are classified into the bracelet and Mobius subfamilies. The bracelet subfamily has previously been shown to display anti-HIV activity. We show here that a member of the Mobius subfamily, kalata B1, also exhibits anti-HIV activity despite extensive sequence differences between the subfamilies. In addition, acyclic permutants of kalata B1 displayed no anti-HIV activity, suggesting that this activity is critically dependent on an intact circular backbone. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved

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External Sources

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  2. DOI: 10.1016/j.febslet.2004.08.007
  3. View record in Web of Science®
  4. WOS: 000224041600012

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