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Direct sequence comparison of two divergent class I MHC natural killer cell receptor haplotypes

  1. Author:
    Makrigiannis, A. P.
    Patel, D.
    Goulet, M. L.
    Dewar, K.
    Anderson, S. K.

  2. Author Address

    Inst Rech Clin Montreal, Lab Mol Immunol, Montreal, PQ H2W 1R7, Canada. Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada. McGill Univ, Dept Med, Div Expt Med, Montreal, PQ, Canada. McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada. McGill Univ, Dept Human Genet, Montreal, PQ, Canada. Genome Quebec Innovat Ctr, Montreal, PQ, Canada. NCI, Basic Res Program, SAIC Frederick, Frederick, MD 21701 USA Makrigiannis, AP, Inst Rech Clin Montreal, Lab Mol Immunol, Rm 1340,110 Ave Pns Ouest, Montreal, PQ H2W 1R7, Canada
    1. Year: 2005
    2. Date: MAR
  2. Journal: Genes and Immunity
    1. 6
    2. 2
    3. Pages: 71-83
  4. Type of Article: Article
  1. Abstract:

    The murine Ly49 gene family encoding natural killer cell receptors for class I MHC is an example of a rapidly evolving cluster of immune response genes. Determining the genomic sequence of the 129S6/SvEvTac (129S6) Ly49 cluster and comparing it to the known sequence of the C57BL/6 (B6) region provided insight into the mechanisms of Ly49 gene evolution. 129S6 contains 20 Ly49, many of which are pseudogenes and 40% of the genes have no counterpart in the B6 genome. The difference in gene content between these two strains is primarily the result of distinct patterns of gene duplication. Phylogenetic analyses of individual exons showed that Ly49 genes form distinct sub-families and an ancestral haplotype can be surmised. Dotplot analysis supports limited allelism in the two haplotypes; however, large regions of variation punctuate these islands of co-linearity. These variable regions contain a high concentration of repetitive elements that are predicted to contribute to the dynamic evolution of this cluster. The extreme variation in Ly49 haplotype content between mouse strains provides a genetic explanation for the documented differences in natural killer cell phenotype, and also indicates that differences in natural killer cell function observed between B6 and 129-derived gene-targeted mice should be interpreted with caution

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External Sources

  1. View record in Web of Science®
  2. WOS: 000227329400001

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