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Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing

  1. Author:
    Bennasser, Y.
    Le, S. Y.
    Benkirane, M.
    Jeang, K. T.

  2. Author Address

    NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA. NCI, Lab Expt & Computat Biol, Canc Res Ctr, Frederick, MD 21702 USA. CNRS, Mol Virol Lab, Inst Genet Humaine, UPR 1142, Montpellier, France Jeang, KT, NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
    1. Year: 2005
    2. Date: MAY
  2. Journal: Immunity
    1. 22
    2. 5
    3. Pages: 607-619
  4. Type of Article: Article
  1. Abstract:

    In plants and invertebrate animals, RNA silencing is a form of nucleic acid-based adaptive immunity. By contrast, jawed vertebrates have evolved complex protein-based adaptive immunity. Although short interfering RNAs (siRNAs) have been used as artificial tools to silence viral infection in human cells, it remains unknown whether mammalian viruses naturally elicit such immunity in vertebral cells. Here, we report the evidence that HIV-1 encodes viral siRNA precursors in its genome and that natural HIV-1 infection provokes nucleic acid-based immunity in human cells. To combat this cellular defense, HIV-1 has evolved in its Tat protein a suppressor of RNA silencing (SRS) function. Tat abrogates the cell's RNA-silencing defense by subverting the ability of Dicer to process precursor double-stranded RNAs into siRNAs

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External Sources

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  2. DOI: 10.1016/j.immuni.2005.03.010
  3. View record in Web of Science®
  4. WOS: 000229447200010

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