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CYP1A1 Val(462) and NQO1 Ser(187) polymorphisms, cigarette use, and risk for colorectal adenoma

  1. Author:
    Hou, L. F.
    Chatterjee, N.
    Huang, W. Y.
    Baccarelli, A.
    Yadavalli, S.
    Yeager, M.
    Bresalier, R. S.
    Chanock, S. J.
    Caporaso, N. E.
    Ji, B. T.
    Weissfeld, J. L.
    Hayes, R. B.

  2. Author Address

    NCI, US Dept HHS, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. NCI, Sect Genom Variat, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA. NCI, SAIC Frederick, Frederick, MD 21701 USA. Univ Texas, MD Anderson Canc Ctr, Dept Gastrointestinal Med & Nutr, Houston, TX 77030 USA. Univ Pittsburgh, Inst Canc, Dept Epidemiol, Pittsburgh, PA USA Hou, LF, NCI, US Dept HHS, Div Canc Epidemiol & Genet, NIH, 6120 Execut Blvd,EPS 8123, Bethesda, MD 20892 USA
    1. Year: 2005
    2. Date: JUN
  2. Journal: Carcinogenesis
    1. 26
    2. 6
    3. Pages: 1122-1128
  4. Type of Article: Article
  1. Abstract:

    Cigarette use is a risk factor for colorectal adenoma, a known precursor of colorectal cancer. Polymorphic variants in NQO1 and CYP1A1 influence the activation of carcinogenic substances in tobacco smoke, possibly impacting on tobacco-associated risks for colorectal tumors. We investigated the association of cigarette smoking with risk for advanced colorectal adenoma in relation to the CYP1A1 Val(462) and NQO1 Ser(187) polymorphic variants. Subjects were 725 non-Hispanic Caucasian cases with advanced colorectal adenoma of the distal colon (descending colon, sigmoid and rectum) and 729 gender- and ethnicity-matched controls, randomly selected from participants in the prostate, lung, colorectal and ovarian cancer screening trial. Subjects carrying either CYP1A1 Val(462) or NQO1 Ser(187) alleles were weakly associated with risk of colorectal adenoma; however, subjects carrying both CYP1A1 Val(462) and NQO1 Ser(187) alleles showed increased risks (OR = 2.2, 95% CI = 1.1-4.5), particularly among recent (including current) (OR = 17.4, 95% CI = 3.8-79.8, P for interaction = 0.02) and heavy cigarette smokers (> 20 cigarettes/day) (OR = 21.1, 95% CI = 3.9-114.4, P for interaction = 0.03) compared with non-smokers who did not carry either of these variants. These genotypes were unassociated with risk in non-smokers. In analysis of adenoma subtypes, the combined gene variants were most strongly associated with the presence of multiple adenoma (P = 0.002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions

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  2. WOS: 000229700100013

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