Skip NavigationSkip to Content
Return Return to Search Results

Evolutionary analysis of a large mtDNA translocation (numt) into the nuclear genome of the Panthera genus species

  1. Author:
    Kim, J. H.
    Antunes, A.
    Luo, S. J.
    Menninger, J.
    Nash, W. G.
    O'Brien, S. J.
    Johnson, W. E.

  2. Author Address

    NCI, Lab Genom Divers, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA. Univ Porto, Fac Ciencias, REQUIMTE, Dept Quim, P-4169007 Oporto, Portugal. NCI, Basic Res Program, SAIC Frederick Inc, Frederick, MD 21702 USA. H&W Cytogenet Serv Inc, Lovettsville, VA USA.;Johnson, WE, NCI, Lab Genom Divers, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.;johnsonw@mail.ncifcrf.gov
    1. Year: 2006
    2. Date: Feb
  2. Journal: Gene
    1. 366
    2. 2
    3. Pages: 292-302
  4. Type of Article: Article
  5. ISSN: 0378-1119
  1. Abstract:

    Translocation of cyrntDNA into the nuclear genome, also referred to as numt, has been reported in many species, including several closely related to the domestic cat (Felis catus). We describe the recent transposition of 12,536 bp of the 17 kb mitochondrial genome into the nucleus of the common ancestor of the five Panthera genus species: tiger, P. tigris; snow leopard, P. uncia; jaguar, P onca; leopard, P. pardus; and lion, P. leo. This nuclear integration, representing 74% of the mitochondrial genome, is one of the largest to be reported in eukaryotes. The Panthera genus numt differs from the mant previously described in the Felis genus in: (1) chromosomal location (F2-telomeric region vs. D2-centromeric region), (2) gene make up (from the ND5 to the ATP8 vs. from the CR to the COII), (3) size (12.5 vs. 7.9 kb), and (4) structure (single monomer vs. tandemly repeated in Felis). These distinctions indicate that the origin of this large numt fragment in the nuclear genome of he Panthera species is an independent insertion from that of the domestic cat lineage, which has been further supported by phylogenetic analyses. The tiger cymtDNA shared around 90% sequence identity with the homologous numt sequence, suggesting an origin for the Panthera numt at around 3.5 million years ago, prior to the radiation of the five extant Panthera species. Published by Elsevier B.V.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.gene.2005.08.023
  3. View record in Web of Science®
  4. WOS: 000236312600011

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel