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CC chemokine MCP-1 induces migration and proliferation of squamous carcinoma cells

  1. Author:
    Gong, X.
    Gong, W.
    Bengali, K.
    Oppenheim, J. J.
    Wang, J. M.
    1. Year of Conference: 1997
  2. Conference Name: Annual Meeting of the American Association for Cancer Research
    1. 38
    2. Pages: A3586
  4. Type of Work: Meeting Abstract
  1. Abstract:

    Chemokines are important mediators of inflammation and immunity, and are mainly active on normal leukocytes. However, some of the chemokines have been reported to affect the growth and metastasis of tumors of non-hematopoietic origin. Several chemokines have been reported to augment anti-tumor immunity. We investigated whether members of the CC chemokine subfamily were able to directly influence the biological behavior of epithelial carcinoma cells. We observed that a human pharyngeal squamous carcinoma cell line, FADU, was able to migrate in response to a concentration gradient of the CC chemokine MCP-1, in association with enhanced adhesion of these cells to endothelial monolayers. FADU cells, when cultured with MCP-1, were induced to proliferate. Scatchard analysis revealed that FADU cells possessed high as well as low affinity binding sites for radio-iodinated MCP-1. Although FADU cells constitutively produced low levels of MCP-1, this production could be markedly increased by inflammatory cytokines IL-1 and TNFalpha. These results suggest that under certain conditions, MCP-1 may serve as a growth and motility stimulating factor for cancer cells. Thus, chemokines also have the potential to increase the growth and spread of tumor cells expressing chemokine binding sites.

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