Skip NavigationSkip to Content
Return Return to Search Results

Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species

  1. Author:
    Takada, K.
    Choi, B. W.
    Rashid, M. A.
    Gamble, W. R.
    Cardellina, J. H.
    Van, Q. N.
    Lloyd, J. R.
    McMahon, J. B.
    Gustafson, K. R.

  2. Author Address

    NCI, Ctr Canc Res, Mol Targets Dev Program, Frederick, MD 21702 USA.;Gustafson, KR, NCI, Ctr Canc Res, Mol Targets Dev Program, Bldg 1052,Room 121, Frederick, MD 21702 USA.;gustafson@ncifcrf.gov
    1. Year: 2007
    2. Date: Mar
  2. Journal: Journal of Natural Products
    1. 70
    2. 3
    3. Pages: 428-431
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    Two new chondropsin-type macrolide lactams, poecillastrins B (1) and C (2), were isolated from aqueous extracts of the marine sponge Poecillastra sp. These trace metabolites were isolated in low yield (400-600 mu g), and their structures were determined primarily by analysis of NMR data acquired using a cyrogenically cooled probe. High-quality 1D and 2D NMR data sets allowed complete assignment of the spectroscopic data and defined the new structures as 35-membered ring analogues of poecillastrin A (3). Compounds 1 and 2 showed potent cytotoxic activity against a human melanoma tumor cell line (LOX) with an IC50 value of less than 1 mu g/mL.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1021/np0604984
  3. View record in Web of Science®
  4. WOS: 000245118800020

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel