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Molecular determinants of HIV-1 intersubtype recombination potential

  1. Author:
    Chin, M. P. S.
    Chen, J. B.
    Nikolaitchik, O. A.
    Hu, W. S.

  2. Author Address

    Natl Canc Inst, HIV Drug Resistance Program, Frederick, MD 21702 USA.;Hu, WS, Natl Canc Inst, HIV Drug Resistance Program, PO Box B Bldg 535, Frederick, MD 21702 USA.;whu@ncifcrf.gov
    1. Year: 2007
    2. Date: Jul
  2. Journal: Virology
    1. 363
    2. 2
    3. Pages: 437-446
  4. Type of Article: Article
  5. ISSN: 0042-6822
  1. Abstract:

    Sequence differences in the dimerization initiation signal (DIS) affect the rate of recombination between subtype B and subtype C HIV-1. To test the hypothesis that DIS sequences can be used to predict intersubtype recombination potentials, we measured the recombination rate between CRF01_A/E (AE) and B, which contain mismatches in the DIS, and between AE and C, which have an identical DIS. Compared with the intrasubtype recombination rate, the recombination rate between AE and subtype B virus was 9-fold lower, and the rate between AE and subtype C virus was 2-fold lower. Thus, DIS sequences can be used to predict the recombination potential between HIV-1 subtypes. Further analyses revealed that the 2-fold lower recombination rate between AE and C viruses can be restored to the intrasubtype recombination rate by matching a part of the LTR and a portion of the viral genome. Therefore, the lower intersubtype recombination rate between AE and C is not caused by a given region but is a cumulative effect by more than one region. Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.virol.2007.01.034
  3. View record in Web of Science®
  4. WOS: 000247058100019

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