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A new strategy for fast radiofrequency CW EPR imaging: Direct detection with rapid scan and rotating gradients

  1. Author:
    Subramanian, S.
    Koscielniak, J. W.
    Devasahayam, N.
    Pursley, R. H.
    Pohida, T. J.
    Krishna, M. C.

  2. Author Address

    NCI, Radiat Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Frederick, MD 21701 USA. NIH, Ctr Informat Technol, Signal Proc & Instrumentat Sect, Bethesda, MD 20892 USA.;Krishna, MC, NCI, Radiat Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.;murali@helix.nih.gov
    1. Year: 2007
    2. Date: Jun
  2. Journal: Journal of Magnetic Resonance
    1. 186
    2. 2
    3. Pages: 212-219
  4. Type of Article: Article
  5. ISSN: 1090-7807
  1. Abstract:

    Rapid field scan on the order of T/s using high frequency sinusoidal or triangular sweep fields superimposed on the main Zeeman field, was used for direct detection of signals without low-frequency field modulation. Simultaneous application of space-encoding rotating field gradients have been employed to perform fast CW EPR imaging using direct detection that could, in principle, approach the speed of pulsed FT EPR imaging. The method takes advantage of the well-known rapid-scan strategy in CW NMR and EPR that allows arbitrarily fast field sweep and the simultaneous application of spinning gradients that allows fast spatial encoding. This leads to fast functional EPR imaging and, depending on the spin concentration, spectrometer sensitivity and detection band width, can provide improved temporal resolution that is important to interrogate dynamics of spin perfusion, pharmacokinetics, spectral spatial imaging, dynamic oxymetry, etc. Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.jmr.2007.01.023
  3. View record in Web of Science®
  4. WOS: 000247490500006

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