Skip NavigationSkip to Content
Return Return to Search Results

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma

  1. Author:
    Daugherty, S. E.
    Platz, E. A.
    Shugart, Y. Y.
    Fallin, M. D.
    Isaacs, W. B.
    Chatterjee, N.
    Welch, R.
    Huang, W. Y.
    Hayes, R. B.

  2. Author Address

    NCI Frederick, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Frederick, MD USA. NCI Frederick, SAIC Frederick Inc, Adv Technol Program, Div Canc Epidemiol & Genet,Core Genotyping Facil, Frederick, MD USA. Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA. Johns Hopkins Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD USA. Johns Hopkins Sch Med, Dept Urol, Baltimore, MD USA. Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA.;Daugherty, SE, NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS Rm 8113, Bethesda, MD 20892 USA.;daughers@mail.nih.gov
    1. Year: 2007
    2. Date: Aug
  2. Journal: Cancer Epidemiology Biomarkers & Prevention
    1. 16
    2. 8
    3. Pages: 1536-1542
  4. Type of Article: Review
  5. ISSN: 1055-9965
  1. Abstract:

    Background: alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer. AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis. Methods: We conducted a case-control study of 725 advanced distal colorectal adenoma cases and 729 frequency-matched controls from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Seven AMACR polymorphisms were genotyped. Unconditional logistic regression models were used to evaluate the associations adjusting for age at randomization and gender. Results: The 201L allele of S201L [TT versus CC: odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.15-2.62; TC versus CC: OR, 1.17; 95% CI, 0.93-1.49] and the 277E allele of K277E (GG versus AA: OR, 1.66; 95% CI, 1.03-2.68; GA versus AA: OR, 1.21; 95% CI, 0.96-1.53) were associated with increased risk of advanced distal colorectal adenoma (both P-trend <= 0.02); the TGTGCG haplotype of six informative single nucleotide polymorphisms was also associated with increased risk (OR, 1.27; 95% CI, 1.03-1.55). Regular ibuprofen users who were homozygous for the variant allele at either M9V or D175G were at reduced risk for adenoma (both P-interaction < 0.05). Conclusion: Our study identified variants in AMACR associated with advanced distal colorectal adenoma and pointed to potential interactions with ibuprofen use.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1158/1055-9965
  3. View record in Web of Science®
  4. WOS: 000248715100003

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel