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Influenza virus not cRAFTy enough to dodge, viperin

  1. Author:
    Waheed, A. A.
    Eric, O.

  2. Author Address

    Natl Canc Inst, HIV Drug Resistance Program, Virus Cell Interact Sect, Frederick, MD 21702 USA.;Eric, O, Natl Canc Inst, HIV Drug Resistance Program, Virus Cell Interact Sect, Frederick, MD 21702 USA.;efreed@nih.gov
    1. Year: 2007
    2. Date: Aug
  2. Journal: Cell Host & Microbe
    1. 2
    2. 2
    3. Pages: 71-72
  4. Type of Article: Editorial Material
  5. ISSN: 1931-3128
  1. Abstract:

    Interferons elicit antiviral responses by inducing the expression of a large number of host cell genes. In this issue of Cell Host & Microbe, Wang and colleagues report that the interferon-inducible protein viperin inhibits influenza A virus release by impairing the formation of cholesterol-enriched plasma membrane microdomains, or lipid rafts. Viperin appears to disrupt lipid rafts by suppressing the activity of farnesyl diphosphate synthase, a key enzyme in isoprenoid biosynthesis.

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External Sources

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  2. DOI: 10.1016/j.chom.2007.07.005
  3. View record in Web of Science®
  4. WOS: 000250203500002

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