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New protein fold revealed by a 1.65 angstrom resolution crystal structure of Francisella tularensis pathogenicity island protein IglC

  1. Author:
    Sun, P.
    Austin, B. P.
    Schubot, F. D.
    Waugh, D. S.

  2. Author Address

    Natl Canc Inst Frederick, Canc Res Ctr, Macromol Crystallog Inst, Frederick, MD 21702 USA.;Waugh, DS, Natl Canc Inst Frederick, Canc Res Ctr, Macromol Crystallog Inst, POB B, Frederick, MD 21702 USA.;waughd@ncifcrf.gov
    1. Year: 2007
    2. Date: Nov
  2. Journal: Protein Science
    1. 16
    2. 11
    3. Pages: 2560-2563
  4. Type of Article: Article
  5. ISSN: 0961-8368
  1. Abstract:

    Francisella tularensis is a highly infectious Gram- negative intracellular pathogen that causes the fulminating disease tularemia and is considered to be a potential bioweapon. F. tularensis pathogenicity island proteins play a key role in modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm of macrophages. The 23 kDa pathogenicity island protein IglC is essential for the survival and proliferation of F. tularensis in macrophages. Seeking to gain some insight into its function, we determined the crystal structure of IglC at 1.65 angstrom resolution. IglC adopts a beta-sandwich conformation that exhibits no similarity with any known protein structure.

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External Sources

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  2. DOI: 10.1110/ps.073177307
  3. View record in Web of Science®
  4. WOS: 000250444400023

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