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Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors

  1. Author:
    Fang, Z. L.
    Song, Y. L.
    Sarkar, T.
    Hamel, E.
    Fogler, W. E.
    Agoston, G. E.
    Fanwick, P. E.
    Cushman, M.

  2. Author Address

    Fang, Zhenglai, Song, Yunlong, Cushman, Mark] Purdue Univ, Sch Pharm & Pharmaceut Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA. [Fang, Zhenglai, Song, Yunlong, Cushman, Mark] Purdue Univ, Purdue Canc Ctr, W Lafayette, IN 47907 USA. [Sarkar, Taradas, Hamel, Ernest] Natl Inst Hlth, Natl Canc Inst, Div Canc Treatment & Diag, Dev Therapeut Program,Toxicol & Pharmacol Branch, Frederick, MD 21702 USA. [Fogler, William E.; Agoston, Gregory E.] EntreMed Inc, Rockville, MD 20850 USA. [Fanwick, Phillip E.] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA.
    1. Year: 2008
  2. Journal: Journal of Organic Chemistry
    1. 73
    2. 11
    3. Pages: 4241-4244
  4. Type of Article: Article
  1. Abstract:

    A series of 3,3-diarylacrylonitriles were synthesized stercoselectively as tubulin polymerization inhibitors for potential use in cancer chemotherapy. This synthetic route features stannylcupration and palladium-catalyzed Stille cross-coupling chemistry, allowing both E and Z isomers of 3,3-diarylacrylonitriles to be prepared in a very short sequence of reactions.

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External Sources

  1. PMID: 18447388

Library Notes

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