Skip NavigationSkip to Content
Return Return to Search Results

Integration of Rous Sarcoma Virus DNA: a CA Dinucleotide Is Not Required for Integration of the U3 End of Viral DNA

  1. Author:
    Oh, J.
    Chang, K. W.
    Hughes, S. H.

  2. Author Address

    Oh, Jangsuk, Chang, Kevin W.; Hughes, Stephen H.] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA. [Oh, Jangsuk] NHLBI, Lab Mol Immunol, Bethesda, MD 20892 USA. [Chang, Kevin W.] NIH, Off Technol Transfer, Rockville, MD USA.
    1. Year: 2008
  2. Journal: Journal of Virology
    1. 82
    2. 22
    3. Pages: 11480-11483
  4. Type of Article: Article
  1. Abstract:

    The two ends of RSV linear DNA are independently inserted into host DNA by integrase in vivo. We previously showed that the range of U3 sequences that are acceptable substrates for integrase appeared to be greater than the range of acceptable U5 sequences in vivo. We have done additional experiments to determine which U3 sequences are good integrase substrates. On the U3 end, there does not appear to be a stringent requirement for the canonical CA, integrase can efficiently remove three nucleotides, and six nucleotides are sufficient to allow integration with reasonable, albeit reduced, efficiency.

    See More

  1. Keywords:

External Sources

  1. PMID: 18768972

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel