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Behavioral characterization of P311 knockout mice

  1. Author:
    Taylor, G. A.
    Rodriguiz, R. M.
    Greene, R. I.
    Daniell, X.
    Henry, S. C.
    Crooks, K. R.
    Kotloski, R.
    Tessarollo, L.
    Phillips, L. E.
    Wetsel, W. C.

  2. Author Address

    Rodriguiz, Ramona M.; Phillips, Lindsey E.; Wetsel, William C.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA. [Taylor, Gregory A.; Greene, Robert I.; Henry, Stanley C.] Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Durham, NC 27705 USA. [Taylor, Gregory A.; Greene, Robert I.; Daniell, Xiaoju, Wetsel, William C.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Taylor, Gregory A.; Daniell, Xiaoju] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA. [Taylor, Gregory A.; Greene, Robert I.; Daniell, Xiaoju] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA. [Crooks, Kristy R.; Kotloski, Robert, Wetsel, William C.] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA. [Wetsel, William C.] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA. [Taylor, Gregory A.; Greene, Robert I.; Daniell, Xiaoju] Duke Univ, Med Ctr, Div Geriatr, Durham, NC 27710 USA. [Taylor, Gregory A.; Greene, Robert I.; Daniell, Xiaoju] Duke Univ, Med Ctr, Ctr Study Aging & Human Dev, Durham, NC 27710 USA. [Rodriguiz, Ramona M.; Phillips, Lindsey E.; Wetsel, William C.] Duke Univ, Med Ctr, Mouse Behav & Neuroendocrine Anal Core Facil, Durham, NC 27710 USA. [Tessarollo, Lino] Ctr Canc Res, Natl Canc Inst, Mouse Canc Genet Program, Frederick, MD USA.
    1. Year: 2008
  2. Journal: Genes Brain and Behavior
    1. 7
    2. 7
    3. Pages: 786-795
  4. Type of Article: Article
  1. Abstract:

    P311 is an 8-kDa protein that is expressed in many brain regions, particularly the hippocampus, cerebellum and olfactory lobes, and is under stringent regulation by developmental, mitogenic and other physiological stimuli. P311 is thought to be involved in the transformation and motility of neural cells, however, its role in normal brain physiology is undefined. To address this point, P311-deficient mice were developed through gene targeting and their behaviors were characterized. Mutants displayed no overt abnormalities, bred normally and had normal survival rates. Additionally, no deficiencies were noted in motor co-ordination, balance, hearing or olfactory discrimination. Nevertheless, P311-deficient mice showed altered behavioral responses in learning and memory. These included impaired responses in social transmission of food preference, Morris water maze and contextual fear conditioning. Additionally, mutants displayed altered emotional responses as indicated by decreased freezing in contextual and cued fear conditioning and reduced fear-potentiated startle. Together, these data establish P311 as playing an important role in learning and memory processes and emotional responses.

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External Sources

  1. PMID: 18616608

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