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Semiconductor Nanocrystals in Autophagy Research: Methodology Improvement at Nanosized Scale

  1. Author:
    Seleverstov, O.
    Phang, J. M.
    Zabirnyk, O.

  2. Author Address

    Seleverstov, Oleksandr] Univ Wyoming, Dept Anim Sci, Coll Agr, Laramie, WY 82071 USA. [Phang, James M.; Zabirnyk, Olga] NCI, Metab & Canc Susceptibil Sect, Comparat Carcinogenesis Lab, Ctr Canc Res, Frederick, MD 21701 USA.
    1. Year: 2009
  2. Book Title: Autophagy in Mammalian Systems
  3. Series Title: Methods in Enzymology
    1. 452, Pt B
    2. Pages: 277-296
  5. Type of Work: Review
  1. Abstract:

    Our recent findings establish a functional link between foreign nanosized bodies and autophagy. We find that nanoparticles (NP) within a certain size range act as potent autophagy activators, and that autophagic flux is an underlying physiological process of the cellular clearance of the NP. Therefore, NP may be used to study and to monitor autophagy. We provide a detailed description of laboratory protocols designed for studying NP-mediated autophagy. In addition, we review available methods of nanotechnotogy, which may benefit autophagy research.

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External Sources

  1. PMID: 19200889

Library Notes

  1. No notes added.
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