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How do transcription factors select specific binding sites in the genome?

  1. Author:
    Pan, Y. P.
    Tsai, C. J.
    Ma, B. Y.
    Nussinov, R.

  2. Author Address

    Pan, Yongping, Tsai, Chung-Jung, Ma, Buyong, Nussinov, Ruth] NCI, Basic Sci Program, SAIC Frederick Inc, Canc Res Nanobiol Program, Frederick, MD 21701 USA. [Nussinov, Ruth] Tel Aviv Univ, Sackler Sch Med, Sackler Inst Mol Med, Dept Human Genet & Mol Med, IL-69978 Tel Aviv, Israel.
    1. Year: 2009
  2. Journal: Nature Structural & Molecular Biology
    1. 16
    2. 11
    3. Pages: 1118-1120
  4. Type of Article: Editorial Material
  1. Abstract:

    How does a transcription factor select a specific DNA response element given the presence of degenerate sequences? To date, this question has largely been viewed from the standpoint of DNA sequence variability and transcription factor binding affinity under steady-state conditions. Here we propose that to address this problem, it is also necessary to account for fluctuating cellular conditions. These lead to dynamic changes in the ensemble of protein (and DNA) conformational states via allosteric effects.

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  2. DOI: 10.1038/nsmb1109-1118
  3. PMID: 19888307

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