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Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

  1. Author:
    Roux, K. J.
    Crisp, M. L.
    Liu, Q.
    Kim, D.
    Kozlov, S.
    Stewart, C. L.
    Burke, B.

  2. Author Address

    Roux, Kyle J.; Crisp, Melissa L.; Liu, Qian, Kim, Daein, Burke, Brian] Univ Florida, Dept Anat & Cell Biol, Gainesville, FL 32610 USA. [Stewart, Colin L.] 8A Biomed Grove, Med Biol Inst, Immunos, Singapore 138648, Singapore. [Kozlov, Serguei] SAIC Frederick Inc, Natl Canc Inst, Ctr Adv Preclin Res, Ft Detrick, MD 21702 USA. [Kozlov, Serguei] SAIC Frederick Inc, Natl Canc Inst, Mouse Canc Genet Program, Ft Detrick, MD 21702 USA.
    1. Year: 2009
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 106
    2. 7
    3. Pages: 2194-2199
  4. Type of Article: Article
  1. Abstract:

    Nucleocytoplasmic coupling is mediated by outer nuclear membrane (ONM) nesprin proteins and inner nuclear membrane Sun proteins. Interactions spanning the perinuclear space create nesprin-Sun complexes connecting the cytoskeleton to nuclear components. A search for proteins displaying a conserved C-terminal sequence present in nesprins 1-3 identified nesprin 4 (Nesp4), a new member of this family. Nesp4 is a kinesin-1-binding protein that displays Sun-dependent localization to the ONM. Expression of Nesp4 is associated with dramatic changes in cellular organization involving relocation of the centrosome and Golgi apparatus relative to the nucleus. These effects can be accounted for entirely by Nesp4's kinesin-binding function. The implication is that Nesp4 may contribute to microtubule-dependent nuclear positioning.

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External Sources

  1. PMID: 19164528

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