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Association of Y chromosome haplogroup I with HIV progression, and HAART outcome

  1. Author:
    Sezgin, E.
    Lind, J. M.
    Shrestha, S.
    Hendrickson, S.
    Goedert, J. J.
    Donfield, S.
    Kirk, G. D.
    Phair, J. P.
    Troyer, J. L.
    O'Brien, S. J.
    Smith, M. W.

  2. Author Address

    Sezgin, Efe, Lind, Joanne M.; Shrestha, Sadeep, Hendrickson, Sher, Goedert, James J.; Donfield, Sharyne, Smith, Michael W.] NCI, Lab Genom Divers, Frederick, MD 21702 USA. [Shrestha, Sadeep, Troyer, Jennifer L.; Smith, Michael W.] SAIC Frederick Inc, NCI Frederick, Basic Res Program, Frederick, MD 21702 USA. [Goedert, James J.] NCI, Viral Epidemiol Branch, Rockville, MD 20582 USA. [Donfield, Sharyne] Rho Inc, Chapel Hill, NC 27517 USA. [Kirk, Gregory D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Phair, John P.] Northwestern Univ, Sch Med, Comprehens AIDS Ctr, Chicago, IL 60611 USA.
    1. Year: 2009
  2. Journal: Human Genetics
    1. 125
    2. 3
    3. Pages: 281-294
  4. Type of Article: Article
  1. Abstract:

    The host genetic basis of differential outcomes in HIV infection, progression, viral load set point and highly active retroviral therapy (HAART) responses was examined for the common Y haplogroups in European Americans and African Americans. Accelerated progression to acquired immune deficiency syndrome (AIDS) and related death in European Americans among Y chromosome haplogroup I (Y-I) subjects was discovered. Additionally, Y-I haplogroup subjects on HAART took a longer time to HIV-1 viral suppression and were more likely to fail HAART. Both the accelerated progression and longer time to viral suppression results observed in haplogroup Y-I were significant after false-discovery-rate corrections. A higher frequency of AIDS-defining illnesses was also observed in haplogroup Y-I. These effects were independent of the previously identified autosomal AIDS restriction genes. When the Y-I haplogroup subjects were further subdivided into six I subhaplogroups, no one subhaplogroup accounted for the effects on HIV progression, viral load or HAART response. Adjustment of the analyses for population stratification found significant and concordant haplogroup Y-I results. The Y chromosome haplogroup analyses of HIV infection and progression in African Americans were not significant. Our results suggest that one or more loci on the Y chromosome found on haplogroup Y-I have an effect on AIDS progression and treatment responses in European Americans.

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  2. DOI: 10.1007/s00439-008-0620-7
  3. PMID: 19169712

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