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A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

  1. Author:
    Venteicher, A. S.
    Abreu, E. B.
    Meng, Z. J.
    McCann, K. E.
    Terns, R. M.
    Veenstra, T. D.
    Terns, M. P.
    Art, i

  2. Author Address

    Venteicher, Andrew S.; McCann, Kelly E.; Artandi, Steven E.] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA. [Venteicher, Andrew S.; Artandi, Steven E.] Stanford Univ, Sch Med, Program Biophys, Stanford, CA 94305 USA. [Abreu, Eladio B.; Terns, Rebecca M.; Terns, Michael P.] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA. [Abreu, Eladio B.; Terns, Rebecca M.; Terns, Michael P.] Univ Georgia, Dept Genet, Athens, GA 30602 USA. [Meng, Zhaojing, Veenstra, Timothy D.] NCI, Lab Proteom & Analyt Technol, Adv Technol Program, Sci Applicat Int Corp, Frederick, MD 21702 USA. [McCann, Kelly E.; Artandi, Steven E.] Stanford Univ, Sch Med, Program Canc Biol, Stanford, CA 94305 USA.
    1. Year: 2009
    2. Date: Jan 30
  2. Journal: Science
    1. 323
    2. 5914
    3. Pages: 644-648
  4. Type of Article: Article
  1. Abstract:

    Telomerase is a ribonucleoprotein ( RNP) complex that synthesizes telomere repeats in tissue progenitor cells and cancer cells. Active human telomerase consists of at least three principal subunits, including the telomerase reverse transcriptase, the telomerase RNA ( TERC), and dyskerin. Here, we identify a holoenzyme subunit, TCAB1 ( telomerase Cajal body protein 1), that is notably enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. TCAB1 associates with active telomerase enzyme, established telomerase components, and small Cajal body RNAs that are involved in modifying splicing RNAs. Depletion of TCAB1 by using RNA interference prevents TERC from associating with Cajal bodies, disrupts telomerase- telomere association, and abrogates telomere synthesis by telomerase. Thus, TCAB1 controls telomerase trafficking and is required for telomere synthesis in human cancer cells.

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  2. DOI: 10.1126/science.1165357
  3. PMID: 19179534
  4. PMCID: PMC2728071

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