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Incorporation of endothelial progenitor cells into the neovasculature of malignant glioma xenograft

  1. Author:
    Zhang, H. R.
    Chen, F. L.
    Xu, C. P.
    Ping, Y. F.
    Wang, Q. L.
    Liang, Z. Q.
    Wang, J. M.
    Bian, X. W.

  2. Author Address

    Zhang, Hua-rong, Chen, Fei-lan, Xu, Chen-ping, Ping, Yi-fang, Wang, Qing-liang, Bian, Xiu-wu] Third Mil Med Univ, Inst Pathol, Southwest Hosp, Chongqing 400038, Peoples R China. [Zhang, Hua-rong, Chen, Fei-lan, Xu, Chen-ping, Ping, Yi-fang, Wang, Qing-liang, Bian, Xiu-wu] Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R China. [Liang, Zi-qing] Third Mil Med Univ, Southwest Hosp, Dept Obstet & Gynecol, Chongqing 400038, Peoples R China. [Wang, Ji Ming] Natl Canc Inst, Ctr Canc Res, Canc & Inflammat Program, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
    1. Year: 2009
  2. Journal: Journal of Neuro-Oncology
    1. 93
    2. 2
    3. Pages: 165-174
  4. Type of Article: Article
  1. Abstract:

    Endothelial progenitor cells (EPCs) are important initiators of vasculogenesis in the process of tumor neovascularization. However, it is unclear how circulating EPCs contribute to the formation of tumor microvessels. In this study, we isolated CD34(+)/CD133(+) cells from human umbilical cord blood (HUCB) and obtained EPCs with the capacities of forming colonies, uptaking acetylated low-density lipoprotein (ac-LDL), binding lectins and expressing vascular endothelial growth factor (VEGF) receptor 2 (VEGFR-2, KDR), CD31 and von Willebrand factor (vWF). These EPCs were actively proliferative and migratory, and could formed capillary-like tubules in response to VEGF. When injected into mice bearing subcutaneously implanted human malignant glioma, EPCs specifically accumulated at the sites of tumors and differentiated into mature endothelial cells (ECs), which accounted for 18% ECs of the tumor microvessels. The incorporation of circulating EPCs into tumor vessel walls significantly affected the morphology and structure of the vasculature. Our results suggest that circulating EPCs constitute important components of tumor microvessel network and contribute to tumor microvascular architecture phenotype heterogeneity.

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External Sources

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  2. DOI: 10.1007/s11060-008-9757-4
  3. PMID: 19052696

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