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Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys

  1. Author:
    Wang, H. B.
    Kondo, A.
    Yoshida, A.
    Yoshizaki, S.
    Abe, S.
    Bao, L. L.
    Mizuki, N.
    Ichino, M.
    Klinman, D.
    Okuda, K.
    Shimada, M.

  2. Author Address

    [Bao, L-L] Peking Union Med Coll, Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China. [Mizuki, N.] Yokohama City Univ, Grad Sch Med, Dept Ophthalmol, Yokohama, Kanagawa 2360004, Japan. [Ichino, M.] Yokohama City Univ, Grad Sch Med, Dept Immunol, Yokohama, Kanagawa 2360004, Japan. [Klinman, D.] NCI, NIH, Frederick, MD 21701 USA.;Shimada, M, Yokohama City Univ, Grad Sch Med, Dept Mol Biodef Res, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan.;mshimada@yokohama-cu.ac.jp
    1. Year: 2010
    2. Date: Jan
  2. Journal: Gene Therapy
    1. 17
    2. 1
    3. Pages: 4-13
  4. Type of Article: Article
  5. ISSN: 0969-7128
  1. Abstract:

    This study explores the effect of priming rhesus monkeys with an Ad5/35 vector expressing simian immunodeficiency virus (SIV) gag and gp120, and then boosting the animals with an modified vaccinia virus Ankara (MVA) vector encoding the same antigens after a 2-month interval. The animals were intravenously challenged with 100 TCID50 of highly pathogenic SIVmac239 virus 2 months after the booster vaccination. The priming vaccination induced robust SIV-specific cell-mediated and humoral immune responses, and boosting further enhanced the cellular immunity. Vaccination reduced peak and long-term viral loads by 1-2 logs for a period of >6 months, as reflected by a reduction in both the SIV RNA and DNA levels. Of considerable interest, the immunized monkeys did not suffer from loss of CD4 T cells, particularly central memory CD4 T cells. These results demonstrate that prophylactic vaccination with Ad5/35 followed by MVA reduces viral replication and prevents CD4 T-cell loss, and that these effects may decrease the likelihood of disease progression. Gene Therapy (2010) 17, 4-13; doi: 10.1038/gt.2009.122; published online 17 September 2009

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External Sources

  1. View Full Text
  2. DOI: 10.1038/gt.2009.122
  3. View record in Web of Science®
  4. WOS: 000273408200002

Library Notes

  1. Fiscal Year: FY2009-2010
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