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Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

  1. Author:
    Schonfeld, S. J.
    Bhatti, P.
    Brown, E. E.
    Linet, M. S.
    Simon, S. L.
    Weinstock, R. M.
    Hutchinson, A. A.
    Stovall, M.
    Preston, D. L.
    Alexander, B. H.
    Doody, M. M.
    Sigurdson, A. J.

  2. Author Address

    [Schonfeld, Sara J.; Linet, Martha S.; Simon, Steven L.; Doody, Michele M.; Sigurdson, Alice J.] NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA. [Bhatti, Parveen] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Brown, Elizabeth E.] Univ Alabama, Dept Epidemiol, Birmingham, AL USA. [Brown, Elizabeth E.] Univ Alabama, Dept Med, Birmingham, AL USA. [Brown, Elizabeth E.] Univ Alabama, Dept Microbiol, Birmingham, AL USA. [Weinstock, Robert M.] RTI Int, Bethesda, MD USA. [Hutchinson, Amy A.] SAIC Frederick Inc, NCI, Core Genotyping Facil, Frederick, MD USA. [Stovall, Marilyn] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA. [Preston, Dale L.] HiroSoft Int Corp, Seattle, WA USA. [Alexander, Bruce H.] Univ Minnesota, Sch Publ Hlth, Div Environm Hlth Sci, Minneapolis, MN USA.;Schonfeld, SJ, NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, 6120 Execut Blvd,MSC 7238, Bethesda, MD 20892 USA.;schonfes@mail.nih.gov
    1. Year: 2010
    2. Date: Nov
  2. Journal: Cancer Causes & Control
    1. 21
    2. 11
    3. Pages: 1857-1866
  4. Type of Article: Article
  5. ISSN: 0957-5243
  1. Abstract:

    Ionizing radiation, an established breast cancer risk factor, has been shown to induce oxidative damage and chronic inflammation. Polymorphic variation in oxidative stress and inflammatory-mediated pathway genes may modify radiation-related breast cancer risk. We estimated breast cancer risk for 28 common variants in 16 candidate genes involved in these pathways among 859 breast cancer cases and 1,083 controls nested within the US Radiologic Technologists cohort. We estimated associations between occupational and personal diagnostic radiation exposures with breast cancer by modeling the odds ratio (OR) as a linear function in logistic regression models and assessed heterogeneity of the dose-response across genotypes. There was suggestive evidence of an interaction between the rs5277 variant in PTGS2 and radiation-related breast cancer risk. The excess OR (EOR)/Gy from occupational radiation exposure = 5.5 (95%CI 1.2-12.5) for the GG genotype versus EOR/Gy < 0 (95%CI < 0-3.8) and EOR/Gy < 0 (95%CI < 0-14.8) for the GC and CC genotypes, respectively, (p (interaction) = 0.04). The association between radiation and breast cancer was not modified by other SNPs examined. This study suggests that variation in PTGS2 may modify the breast cancer risk from occupational radiation exposure, but replication in other populations is needed to confirm this result.

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External Sources

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  2. DOI: 10.1007/s10552-010-9613-7
  3. View record in Web of Science®
  4. WOS: 000283359400011

Library Notes

  1. Fiscal Year: FY2010-2011
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