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Cyp2e1 Genetic Polymorphisms and Risk of Nasopharyngeal Carcinoma in Taiwan

  1. Author:
    Hildesheim, A.
    Anderson, L. M.
    Chen, C. J.
    Cheng, Y. J.
    Brinton, L. A.
    Daly, A. K.
    Reed, C. D.
    Chen, I. H.
    Caporaso, N. E.
    Hsu, M. M.
    Chen, J. Y.
    Idle, J. R.
    Hoover, R. N.
    Yang, C. S.
    Chhabra, S. K.

  2. Author Address

    Hildesheim A NATL INST HLTH EXECUT PLAZA N RM 443 BETHESDA, MD 20892 USA NATL CANC INST DIV CANC EPIDEMIOL & GENET BETHESDA, MD USA NCI COMPARAT CARCINOGENESIS LAB FREDERICK CANC RES & DEV CTR FREDERICK, MD 21702 USA NATL TAIWAN UNIV COLL PUBL HLTH INST EPIDEMIOL TAIPEI 10764 TAIWAN NATL TAIWAN UNIV COLL MED INST MICROBIOL TAIPEI 10764 TAIWAN GENOTYPE LTD NEWCASTLE UPON TYNE TYNE & WEAR ENGLAND MCKAY MEM HOSP DEPT OTOLARYNGOL TAIPEI TAIWAN NATL TAIWAN UNIV HOSP DEPT OTOLARYNGOL TAIPEI TAIWAN
    1. Year: 1997
  2. Journal: Journal of the National Cancer Institute
    1. 89
    2. 16
    3. Pages: 1207-1212
  4. Type of Article: Article
  1. Abstract:

    Background: Nasopharyngeal carcinoma occurs disproportionately among individuals of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is known to activate nitrosamines and other carcinogens that are possibly involved in the development of this disease. Certain alleles of the CYP2E1 gene are thought to be more highly expressed than others, and their distribution varies between Asian and Caucasian populations. We conducted a case-control study to investigate whether such variations affect the risk of developing nasopharyngeal cancer. Methods: Three hundred sixty-four patients with nasopharyngeal carcinoma (96% of 378 eligible patients) and 320 control subjects (86% of 374 eligible subjects) were studied. A risk factor questionnaire was administered to participants to assess factors postulated to be linked to nasopharyngeal carcinoma, Peripheral blood was obtained from all subjects and DNA was purified from nucleated cells. A polymerase chain reaction-based restriction fragment length polymorphism assay that used the restriction enzymes Rsa I and Dra I was used to detect wild-type and variant forms of the CYP2E1 gene. Results: Individuals homozygous for an allele of the CYPSE1 gene that is detected by Rsa I digestion (c2 allele) were found to have an increased risk of nasopharyngeal carcinoma (relative risk [RR] 2.6; 95% confidence interval [CI] 1.2-5.7); this effect was limited to nonsmokers (RR = 9.3; 95% CI = 2.7-32) and was not affected by alcohol consumption, Conclusions: Our findings suggest that the CYP2E1 genotype is a determinant of nasopharyngeal carcinoma risk. [References: 47]

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External Sources

  1. View record in Web of Science®
  2. WOS: A1997XR14900009

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