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HCV Peptide (C5A), an Amphipathic alpha-Helical Peptide of Hepatitis Virus C, Is an Activator of N-Formyl Peptide Receptor in Human Phagocytes

  1. Author:
    Lin, Q.
    Fang, D.
    Hou, X. W.
    Le, Y. Y.
    Fang, J. H.
    Wen, F.
    Gong, W. H.
    Chen, K. Q.
    Wang, J. M.
    Su, S. B.

  2. Author Address

    [Lin, Qing; Fang, Dan; Fang, Jiazhu; Wen, Feng; Su, Shao Bo] Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510275, Guangdong, Peoples R China. [Hou, Xinwei; Le, Yingying] Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China. [Gong, Wanghua] Sci Applicat Int Corp Frederick, Basic Res Program, Frederick, MD 21702 USA. [Chen, Keqiang; Wang, Ji Ming] NCI, Ctr Canc Res, Lab Mol Immunoregulat Canc & Inflammat Prog, Frederick, MD 21702 USA.;Su, SB, Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, 54 S Xianlie Rd, Guangzhou 510275, Guangdong, Peoples R China.;shaobo.su@gmail.com
    1. Year: 2011
    2. Date: Feb
  2. Journal: Journal of Immunology
    1. 186
    2. 4
    3. Pages: 2087-2094
  4. Type of Article: Article
  5. ISSN: 0022-1767
  1. Abstract:

    The hepatitis C virus (HCV) nonstructural 5A, a phosphorylated zinc metalloprotein, is an essential component of the HCV replication complex. An amphipathic alpha-helical peptide (HCV peptide [C5A]) derived from nonstructural 5A membrane anchor domain possesses potent anti-HCV and anti-HIV activity in vitro. In this study, we aimed to investigate the potential of HCV peptide (C5A) to regulate host immune responses. The capacity of HCV peptide (C5A) in vitro to induce migration and calcium mobilization of human phagocytes and chemoattractant receptor-transfected cells was investigated. The recruitment of phagocytes in vivo induced by HCV peptide (C5A) and its adjuvant activity were examined. The results revealed that HCV peptide (C5A) was a chemoattractant and activator of human phagocytic leukocytes by using a G-protein coupled receptor, namely formyl peptide receptor. In mice, HCV peptide (C5A) induced massive phagocyte infiltration after injection in the air pouch or the s.c. region. HCV peptide (C5A) also acted as an immune adjuvant by enhancing specific T cell responses to Ag challenge in mice. Our results suggest that HCV peptide (C5A) derived from HCV regulates innate and adaptive immunity in the host by activating the formyl peptide receptor. The Journal of Immunology, 2011, 186: 2087-2094.

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External Sources

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  2. DOI: 10.4049/jimmunol.1002340
  3. View record in Web of Science®
  4. WOS: 000286882700027

Library Notes

  1. Fiscal Year: FY2010-2011
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