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Self-Assembling RNA Nanorings Based on RNAI/II Inverse Kissing Complexes

  1. Author:
    Grabow, W. W.
    Zakrevsky, P.
    Afonin, K. A.
    Chworos, A.
    Shapiro, B. A.
    Jaeger, L.

  2. Author Address

    [Grabow, Wade W.; Zakrevsky, Paul; Afonin, Kirill A.; Chworos, Arkadiusz; Jaeger, Luc] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. [Shapiro, Bruce A.] NCI, Ctr Canc Res, Nanobiol Program, NIH, Frederick, MD 21702 USA. [Jaeger, Luc] Univ Calif Santa Barbara, Biomol Sci & Engn Program, Santa Barbara, CA 93106 USA.;Jaeger, L, Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA.;jaeger@chem.ucsb.edu
    1. Year: 2011
    2. Date: Feb
  2. Journal: Nano Letters
    1. 11
    2. 2
    3. Pages: 878-887
  4. Type of Article: Article
  5. ISSN: 1530-6984
  1. Abstract:

    RNA is an attractive biopolymer for nanodesign of self-assembling particles for nanobiotechnology and synthetic biology. Here, we experimentally characterize by biochemical and biophysical methods the formation of thermostable and ribonuclease resistant RNA nanorings previously proposed by computational design. High yields of fully programmable nanorings were produced based on several RNAI/II kissing complex variants selected for their ability to promote polygon self-assembly. This self-assembly strategy relying on the particular geometry of bended kissing complexes has potential for developing short interfering RNA delivery agents.

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External Sources

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  2. DOI: 10.1021/nl104271s
  3. View record in Web of Science®
  4. WOS: 000287049100096

Library Notes

  1. Fiscal Year: FY2010-2011
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