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  1. 1.   Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site
  2. Calvo, E.; Barasoain, I.; Matesanz, R.; Pera, B.; Camafeita, E.; Pineda, O.; Hamel, E.; Vanderwal, C. D.; Andreu, J. M.; Lopez, J. A.; Diaz, J. F.
  3. Biochemistry. 2012, Jan; 51(1): 329-341.
  1. 2.   Synthesis and Biological Activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyri midin-4-aminium Chloride as Potent Cytotoxic Antitubulin Agents
  2. Ganglee, A.; Zhao, Y.; Hamel, E.; Westbrook, C.; Mooberry, S. L.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6151-6155.
  1. 3.   Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance
  2. Gangjee, A.; Zhao, Y.; Lin, L.; Raghavan, S.; Roberts, E. G.; Risinger, A. L.; Hamel, E.; Mooberry, S. L.
  3. Journal of Medicinal Chemistry. 2010, Nov; 53(22): 8116-8128.
  1. 4.   The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [H-3]Peloruside A
  2. Nguyen, T. L.; Xu, X. M.; Gussio, R.; Ghosh, A. K.; Hamel, E.
  3. Journal of Chemical Information and Modeling. 2010, Nov; 50(11): 2019-2028.
  1. 5.   Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole
  2. Mooberry, S. L.; Weiderhold, K. N.; Dakshanamurthy, S.; Hamel, E.; Banner, E. J.; Kharlamova, A.; Hempel, J.; Gupton, J. T.; Brown, M. L.
  3. Molecular Pharmacology. 2007, Jul; 72(1): 132-140.
  1. 6.   Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer
  2. Jimeno, A.; Hallur, G.; Chan, A.; Zhang, X. F.; Cusatis, G.; Chan, F.; Shah, P.; Chen, R. B.; Hamel, E.; Garrett-Mayer, E.; Khan, S.; Hidalgo, M.
  3. Molecular Cancer Therapeutics. 2007, May; 6(5): 1509-1516.
  1. 7.   Taxoids: Cancer-fighting compounds from nature
  2. Kingston, D. G. I.; Newman, D. J.
  3. Current Opinion in Drug Discovery & Development. 2007, Mar; 10(2): 130-144.
  1. 8.   Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
  2. Buey, R. M.; Calvo, E.; Barasoain, I.; Pineda, O.; Edler, M. C.; Matesanz, R.; Cerezo, G.; Vanderwal, C. D.; Day, B. W.; Sorensen, E. J.; Lopez, J. A.; Andreu, J. M.; Hamel, E.; Diaz, J. F.
  3. Nature Chemical Biology. 2007, Feb; 3(2): 117-125.
  1. 9.   Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin
  2. Dabydeen, D. A.; Burnett, J. C.; Bai, R. L.; Verdier-Pinard, P.; Hickford, S. J. H.; Pettit, G. R.; Blunt, J. W.; Munro, M. H. G.; Gussio, R.; Hamel, E.
  3. Molecular Pharmacology. 2006, Dec; 70(6): 1866-1875.
  1. 10.   Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin
  2. Madiraju, C.; Edler, M. C.; Hamel, E.; Raccor, B. S.; Balachandran, R.; Zhu, G. Y.; Giuliano, K. A.; Vogt, A.; Shin, Y. S.; Fournier, J. H.; Fukui, Y. H.; Bruckner, A. M.; Curran, D. P.; Day, B. W.
  3. Biochemistry. 2005, NOV 15; 44(45): 15053-15063.
  1. 11.   Synthesis and biological evaluation of (-)-16-normethyldictyostatin: A potent analogue of (-)-dictyostatin
  2. Shin, Y.; Fournier, J. H.; Balachandran, R.; Madiraju, C.; Raccor, B. S.; Zhu, G.; Edler, M. C.; Hamel, E.; Day, B. W.; Curran, D. P.
  3. Organic Letters. 2005, JUL 7; 7(14): 2873-2876.
  1. 12.   Neural crest stem cell and cardiac endothelium defects in the TrkC null mouse
  2. Youn, Y. H.; Feng, J.; Tessarollo, L.; Ito, K.; Sieber-Blum, M.
  3. Molecular and Cellular Neuroscience. 2003 24(1): 160-170.
  1. 13.   Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin
  2. Hamel, E.
  3. Cell Biochemistry and Biophysics. 2003 38(1): 1-21.
  1. 14.   The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity
  2. Pryor, D. E.; O'Brate, A.; Bilcer, G.; Diaz, J. F.; Wang, Y. F.; Wang, Y.; Kabaki, M.; Jung, M. K.; Andreu, J. M.; Ghosh, A. K.; Giannakakou, P.; Hamel, E.
  3. Biochemistry. 2002 41(29): 9109-9115.
  1. 15.   Relating molecular flexibility to function: A case study of tubulin
  2. Keskin, O.; Durell, S. R.; Bahar, I.; Jernigan, R. L.; Covell, D. G.
  3. Biophysical Journal. 2002 83(2): 663-680.
  1. 16.   Interactions of antimitotic peptides and depsipeptides with tubulin
  2. Hamel, E.
  3. Biopolymers. 2002 66(3): 142-160.
  1. 17.   A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
  2. Giannakakou, P.; Gussio, R.; Nogales, E.; Downing, K. H.; Zaharevitz, D.; Bollbuck, B.; Poy, G.; Sackett, D.; Nicolaou, K. C.; Fojo, T.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2000 97(6): 2904-2909.
  1. 18.   A steroid derivative with paclitaxel-like effects on tubulin polymerization
  2. Verdier-Pinard, P.; Wang, Z. Q.; Mohanakrishnan, A. K.; Cushman, M.; Hamel, E.
  3. Molecular Pharmacology. 2000 57(3): 568-575.
  1. 19.   Interaction of novel thiocolchicine analogs with the tubulin isoforms from bovine brain
  2. Banerjee, A.; Kasmala, L. T.; Hamel, E.; Sun, L.; Lee, K. H.
  3. Biochemical and Biophysical Research Communications. 1999 254(2): 334-337.
  1. 20.   Synthesis and biological activity of a novel C4-C6 bridged paclitaxel analog
  2. Yuan, H. Q.; Kingston, D. G. I.; Sackett, D. L.; Hamel, E.
  3. Tetrahedron. 1999 55(32): 9707-9716.
  1. 21.   Purification, characterization, and drug susceptibility of tubulin from Leishmania
  2. Werbovetz, K. A.; Brendle, J. J.; Sackett, D. L.
  3. Molecular and Biochemical Parasitology. 1999 98(1): 53-65.
  1. 22.   Direct Photoaffinity Labeling of Cysteine-295 of Alpha-Tubulin By Guanosine 5'-Triphosphate Bound in the Nonexchangeable Site
  2. Bai, R. L.; Choe, K.; Ewell, J. B.; Nguyen, N. Y.; Hamel, E.
  3. Journal of Biological Chemistry. 1998 273(16): 9894-9897.
  1. 23.   Activities of the Microtubule-Stabilizing Agents Epothilones a and B With Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol(R))
  2. Kowalski, R. J.; Giannakakou, P.; Hamel, E.
  3. Journal of Biological Chemistry. 1997 272(4): 2534-2541.
  1. 24.   Designed Epothilones - Combinatorial Synthesis, Tubulin Assembly Properties, and Cytotoxic Action Against Taxol-Resistant Tumor Cells
  2. Nicolaou, K. C.; Vourloumis, D.; Li, T. H.; Pastor, J.; Winssinger, N.; He, Y.; Ninkovic, S.; Sarabia, F.; Vallberg, H.; Roschangar, F.; King, N. P.; Finlay, M. R. V.; Giannakakou, P.; Verdierpinard, P.; Hamel, E.
  3. Angewandte Chemie-International Edition. 1997 36(19): 2097-2103.
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