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  1. 1.   Membrane-Surface Anchoring of Charged Diacylglycerol-Lactones Correlates with Biological Activities
  2. Raifman, O.; Kolusheva, S.; El Kazzouli, S.; Sigano, D. M.; Kedei, N.; Lewin, N. E.; Lopez-Nicolas, R.; Ortiz-Espin, A.; Gomez-Fernandez, J. C.; Blumberg, P. M.; Marquez, V. E.; Corbalan-Garcia, S.; Jelinek, R.
  3. Chembiochem. 2010, Sep; 11(14): 2003-2009.
  1. 2.   Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities
  2. Raifman, O.; Kolusheva, S.; Comin, M. J.; Kedei, N.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.; Jelinek, R.
  3. Febs Journal. 2010, Jan; 277(1): 233-243.
  1. 3.   Ceramides: Branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency
  2. Kang, J. H.; Garg, H.; Sigano, D. M.; Francella, N.; Blumenthal, R.; Marquez, V. E.
  3. Bioorganic & Medicinal Chemistry. 2009 17(4): 1498-1505.
  1. 4.   Lipid-Modulated Pharmacophore Nanorods Assembled at the Air/Water Interface
  2. Philosof-Mazor, L.; Volinsky, R.; Jopp, J.; Blumberg, P.; Rapaport, H.; Marquez, V. E.; Jelinek, R.
  3. Chemphyschem. 2009 10(15): 2615-2619.
  1. 5.   Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
  2. Duan, D.; Sigano, D. M.; Kelley, J. A.; Lai, C. C.; Lewin, N. E.; Kedei, N.; Peach, M. L.; Lee, J.; Abeyweera, T. P.; Rotenberg, S. A.; Kim, H.; Kim, Y. H.; El Kazzouli, S.; Chung, J. U.; Young, H. A.; Young, M. R.; Baker, A.; Colburn, N. H.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5198-5220.
  1. 6.   Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins
  2. El Kazzouli, S.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5371-5386.
  1. 7.   Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface
  2. Philosof-Mazor, L.; Volinsky, R.; Comin, M. J.; Lewin, N. E.; Kedei, N.; Blumberg, P. M.; Marquez, V. E.; Jelinek, R.
  3. Langmuir. 2008 24(19): 11043-11052.
  1. 8.   Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C)
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Peach, M. L.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004, SEP 23; 47(20): 4858-4864.
  1. 9.   The discovery of protein kinase C (PK-C) isozyme: Specific ligands driven by a solid-phase combinatorial synthesis of diacylglycerol-lactones (DAG-lactones)
  2. Duan, D. H.; Peach, M. L.; Lai, C. C.; Lewin, N. E.; Kelley, J. A.; Blumberg, P. M.; Marquez, V. E.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 177-MEDI, Abstract U939-177-MEDI, Abstract U939.
  1. 10.   Hydrophobic ligand-protein interactions vs. ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C)
  2. Sigano, D. M.; Tamamura, H.; Lewin, N. E.; Peach, M. L.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 229-MEDI, Abstract U949-229-MEDI, Abstract U949.
  1. 11.   New design approaches aimed at targeting atypical PKC isoform zeta with diacylglycerol-lactones (DAG-lactones)
  2. Kang, J. H.; Peach, M. L.; Blumberg, P. M.; Marquez, V. E.
  3. Abstracts of Papers of the American Chemical Society. 2004, MAR 28; 227(031-MEDI, Part 2): U10-U10.
  1. 12.   Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004 47(3): 644-655.
  1. 13.   Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands
  2. Lee, J.; Kim, S. Y.; Kang, J. H.; Acs, G.; Acs, P.; Blumberg, P. M.; Marquez, V. E.
  3. European Journal of Medicinal Chemistry. 2004 39(1): 69-77.
  1. 14.   Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKC alpha
  2. Garcia-Bermejo, M. L.; Leskow, F. C.; Fujii, T.; Wang, Q. M.; Blumberg, P. M.; Ohba, M.; Kuroki, T.; Han, K. C.; Lee, J.; Marquez, V. E.; Kazanietz, M. G.
  3. Journal of Biological Chemistry. 2002 277(1): 645-655.
  1. 15.   Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4- disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity
  2. Nacro, K.; Lee, J.; Barchi, J. J.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Tetrahedron. 2002 58(26): 5335-5345.
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