Selective Bibliography of Dr. Zhijian "James" Chen
University of Texas Southwestern

Thursday, May 13, 2021

1.  Yum S, Li M, Fang Y, Chen ZJ
TBK1 recruitment to STING activates both IRF3 and NF-?B that mediate immune defense against tumors and viral infections
Proceedings of the National Academies of Science of the United States of America 118 (14):Apr 6 2021

2.  Li T, Huang T, Du M, Chen X, Du F, Ren J, Chen ZJ
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Science 371 (6535):Mar 19 2021

3.  Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Cancer Cell 39 (1):109-121.e5 Jan 11 2021

4.  Zhang BC, Nandakumar R, Reinert LS, Huang J, Laustsen A, Gao ZL, Sun CL, Jensen SB, Troldborg A, Assil S, Berthelsen MF, Scavenius C, Zhang Y, Windross SJ, Olagnier D, Prabakaran T, Bodda C, Narita R, Cai Y, Zhang CG, Stenmark H, Doucet CM, Noda T, Guo Z, Goldbach-Mansky R, Hartmann R, Chen ZJ, Enghild JJ, Bak RO, Thomsen MK, Paludan SR
STEEP mediates STING ER exit and activation of signaling
Nature Immunology 21 (8):868-879 Aug 2020

5.  Padilla-Salinas R, Sun L, Anderson R, Yang X, Zhang S, Chen ZJ, Yin H
Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors
Journal of Organic Chemistry 85 (3):1579-1600 Feb 7 2020

6.  Zhang C, Shang G, Gui X, Zhang X, Bai XC, Chen ZJ
Structural basis of STING binding with and phosphorylation by TBK1
Nature 567 (7748):394-398 Mar 2019

7.  Shang G, Zhang C, Chen ZJ, Bai XC, Zhang X
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP
Nature 567 (7748):389-393 Mar 2019

8.  Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen ZJ
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Nature 567 (7747):262-266 Mar 2019

9.  Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, Kim M, Thompson MG, García-Sastre A, Lynch KW, Chen ZJ, Chook YM, Fontoura BMA
Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression
Proceedings of the National Academies of Science of the United States of America 115 (52):E12218-e12227 Dec 26 2018

10.  Chen J, Chen ZJ
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
Nature 564 (7734):71-76 Dec 2018



Date Last Updated: 2/23/2021

Date Last Updated: 4/22/2021