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Gut microbiota and probiotics in colon tumorigenesis

  1. Author:
    Zhu, Y. M.
    Luo, T. M.
    Jobin, C.
    Young, H. A.

  2. Author Address

    [Young, HA] Natl Canc Inst, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21702 USA. [Zhu, YM] Beijing Univ, Peoples Hosp, Dept Digest Dis, Beijing 100871, Peoples R China. [Jobin, C] Univ N Carolina, Div Gastroenterol & Hepatol, Chapel Hill, NC USA. [Luo, TM] US FDA, CDRH, OIVD, Silver Spring, MD USA.;Young, HA (reprint author), Natl Canc Inst, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Bldg 560-31-23,Chandler St, Frederick, MD 21702 USA;YoungHow@mail.nih.gov
    1. Year: 2011
    2. Date: Oct
  2. Journal: Cancer Letters
    1. 309
    2. 2
    3. Pages: 119-127
  4. Type of Article: Review
  5. ISSN: 0304-3835
  1. Abstract:

    The human gastrointestinal tract harbors a complex and abundant microbial community reaching as high as 10(13)-10(14) microorganisms in the colon. This endogenous microbiota forms a symbiotic relationship with their eukaryotic host and this close partnership helps maintain homeostasis by performing essential and non-redundant tasks (e.g. nutrition/energy and, immune system balance, pathogen exclusion). Although this relationship is essential and beneficial to the host, various events (e.g. infection, diet, stress, inflammation) may impact microbial composition, leading to the formation of a dysbiotic microbiota, further impacting on health and disease states. For example, Crohn's disease and ulcerative colitis, collectively termed inflammatory bowel diseases (IBD), have been associated with the establishment of a dysbiotic microbiota. In addition, extra-intestinal disorders such as obesity and metabolic syndrome are also associated with the development of a dysbiotic microbiota. Consequently, there is an increasing interest in harnessing the power of the microbiome and modulating its composition as a means to alleviate intestinal pathologies/disorders and maintain health status. In this review, we will discuss the emerging relationship between the microbiota and development of colorectal cancer as well as present evidence that microbial manipulation (probiotic, prebiotic) impacts disease development. Published by Elsevier Ireland Ltd.

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External Sources

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  2. DOI: 10.1016/j.canlet.2011.06.004
  3. View record in Web of Science®
  4. WOS: 000294576400001

Library Notes

  1. Fiscal Year: FY2011-2012
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