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Genome-wide association study identifies new prostate cancer susceptibility loci

  1. Author:
    Schumacher, F. R.
    Berndt, S. I.
    Siddiq, A.
    Jacobs, K. B.
    Wang, Z. M.
    Lindstrom, S.
    Stevens, V. L.
    Chen, C.
    Mondul, A. M.
    Travis, R. C.
    Stram, D. O.
    Eeles, R. A.
    Easton, D. F.
    Giles, G.
    Hopper, J. L.
    Neal, D. E.
    Hamdy, F. C.
    Donovan, J. L.
    Muir, K.
    Al Olama, A. A.
    Kote-Jarai, Z.
    Guy, M.
    Severi, G.
    Gronberg, H.
    Isaacs, W. B.
    Karlsson, R.
    Wiklund, F.
    Xu, J. F.
    Allen, N. E.
    Andriole, G. L.
    Barricarte, A.
    Boeing, H.
    Bueno-de-Mesquita, H. B.
    Crawford, E. D.
    Diver, W. R.
    Gonzalez, C. A.
    Gaziano, J. M.
    Giovannucci, E. L.
    Johansson, M.
    Le Marchand, L.
    Ma, J.
    Sieri, S.
    Stattin, P.
    Stampfer, M. J.
    Tjonnel, A.
    Vineis, P.
    Virtamo, J.
    Vogel, U.
    Weinstein, S. J.
    Yeager, M.
    Thun, M. J.
    Kolonel, L. N.
    Henderson, B. E.
    Albanes, D.
    Hayes, R. B.
    Feigelson, H. S.
    Riboli, E.
    Hunter, D. J.
    Chanock, S. J.
    Haiman, C. A.
    Kraft, P.

  2. Author Address

    [Lindstrom, S; Chen, C; Hunter, DJ; Kraft, P] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA. [Schumacher, FR; Stram, DO; Henderson, BE; Haiman, CA] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA. [Berndt, SI; Jacobs, KB; Wang, ZM; Mondul, AM; Weinstein, SJ; Yeager, M; Albanes, D; Hayes, RB; Chanock, SJ] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Siddiq, A; Riboli, E] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England. [Vineis, P] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC HPA Ctr Environm & Hlth, London, England. [Jacobs, KB; Wang, ZM] NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA. [Jacobs, KB] Bioinformed Consulting Serv, Gaithersburg, MD USA. [Lindstrom, S; Chen, C; Giovannucci, EL; Stampfer, MJ; Hunter, DJ; Kraft, P] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Giovannucci, EL; Stampfer, MJ] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Stevens, VL; Diver, WR; Thun, MJ] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. [Travis, RC; Allen, NE] Univ Oxford, Canc Epidemiol Unit, Oxford, England. [Travis, RC; Allen, NE] Univ Oxford, Nuffield Dept Clin Med, Oxford, England. [Hamdy, FC] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England. [Eeles, RA; Kote-Jarai, Z; Guy, M] Inst Canc Res, Oncogenet Team, Sutton, Surrey, England. [Easton, DF; Al Olama, AA] Univ Cambridge, Ctr Canc Genet Epidemiol, Cambridge, England. [Easton, DF; Al Olama, AA] Univ Cambridge, Dept Publ Hlth, Cambridge, England. [Easton, DF; Al Olama, AA] Univ Cambridge, Dept Primary Care, Cambridge, England. [Easton, DF; Neal, DE] Univ Cambridge, Dept Oncol, Cambridge, England. [Giles, G; Severi, G] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia. [Hopper, JL] Univ Melbourne, Melbourne Sch Populat Hlth, Ctr Mol Environm Genet & Analyt MEGA Epidemiol, Melbourne, Vic, Australia. [Donovan, JL] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England. [Muir, K] Univ Warwick, Hlth Sci Res Inst, Coventry CV4 7AL, W Midlands, England. [Gronberg, H; Karlsson, R; Wiklund, F] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Isaacs, WB] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA. [Xu, JF] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC USA. [Xu, JF] Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA. [Andriole, GL] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA. [Barricarte, A] Navarre Publ Hlth Inst, Pamplona, Spain. [Boeing, H] Deutsch Inst Ernahrungsforsch, Dept Epidemiol, Potsdam, Germany. [Bueno-de-Mesquita, HB] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Crawford, ED] Univ Colorado, Aurora, CO USA. [Gonzalez, CA] Catalan Inst Oncol ICO IDIBELL RETICC RD06 0020, Unit Nutr Environm & Canc, Barcelona, Spain. [Gaziano, JM] Brigham & Womens Hosp, Div Aging, Boston, MA 02115 USA. [Ma, J; Stampfer, MJ] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Gaziano, JM] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, VA Cooperat Studies Programs, Boston, MA USA. [Gaziano, JM; Ma, J; Stampfer, MJ] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Johansson, M] Int Agcy Res Canc, F-69372 Lyon, France. [Johansson, M; Stattin, P] Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden. [Le Marchand, L; Kolonel, LN] Univ Hawaii, Canc Res Ctr Hawaii, Honolulu, HI 96813 USA. [Ma, J; Stampfer, MJ] Channing Labs, Boston, MA USA. [Sieri, S] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy. [Tjonneland, A] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Virtamo, J] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Vogel, U] Natl Res Ctr Working Environm, Copenhagen, Denmark. [Vogel, U] Tech Univ Denmark, Natl Food Inst, Soborg, Denmark. [Hayes, RB] NYU, Dept Environm Med, Inst Canc, Div Epidemiol,Langone Med Ctr, New York, NY 10016 USA. [Feigelson, HS] Kaiser Permanente, Inst Hlth Res, Denver, CO USA.;Kraft, P (reprint author), Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, 665 Huntington Ave, Boston, MA 02115 USA;pkraft@hsph.harvard.edu
    1. Year: 2011
    2. Date: Oct
  2. Journal: Human Molecular Genetics
    1. 20
    2. 19
    3. Pages: 3867-3875
  4. Type of Article: Article
  5. ISSN: 0964-6906
  1. Abstract:

    Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade >= 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 x 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 x 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P = 0.72 and P = 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.

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  2. DOI: 10.1093/hmg/ddr295
  3. View record in Web of Science®
  4. WOS: 000294810000014

Library Notes

  1. Fiscal Year: FY2011-2012
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