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Murine GBP-2: A new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages

  1. Author:
    Vestal, D. J.
    Buss, J. E.
    McKercher, S. R.
    Jenkins, N. A.
    Copeland, N. G.
    Kelner, G. S.
    Asundi, V. K.
    Maki, R. A.

  2. Author Address

    Vestal DJ Cleveland Clin Fdn, Dept Biol Mol 9500 Euclid Ave Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Biol Mol Cleveland, OH 44195 USA Burnham Inst La Jolla, CA 92037 USA Iowa State Univ, Dept Biochem & Biophys Ames, IA 50011 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA Neurocrine Biosci Inc La Jolla, CA 92037 USA Geisinger Med Clin, Sigfried & Janet Weis Ctr Res Danville, PA 17822 USA
    1. Year: 1998
  2. Journal: Journal of Interferon and Cytokine Research
    1. 18
    2. 11
    3. Pages: 977-985
  4. Type of Article: Article
  1. Abstract:

    We have cloned a new member of the interferon (IFN)-induced guanylate-binding protein (GBP) family of GTPases, murine GBP-2 (mGBP-2), from bone marrow-derived macrophages, mGBP-2 is located on murine chromosome 3, where it is linked to mGBP-1, With the identification of mGBP-2 there are now two human and two murine GBPs, Like other GBPs, mGBP-2 RNA and protein are induced by IFN-gamma, In addition, mGBP-2 shares with the other GBPs important structural features that distinguish this family from other GTPases, First, mGBP-2 contains only two of the three consensus sequences for nucleotide binding found within the classic GTP binding regions of other GTPases, A second amino acid motif found in mGBP-2 is a potential C-terminal site for isoprenoid modification, called a CaaX sequence. mGBP-2 is prenylated, as detected by [H-3]mevalonate incorporation, when expressed in COS cells and preferentially incorporates the C-20 isoprenoid geranylgeraniol, Surprisingly, despite having a functional CaaX sequence, mGBP-2 is primarily cytosolic, GBP proteins are very abundant in IFN-exposed cells, but little is known about their function. mGBP-2 is expressed by IFN-gamma-treated cells from C57Bl/6 mice, whereas mGBP-1 is not. Thus, the identification of mGBP-2 makes possible the study of GBP function in the absence of a second family member. [References: 58]

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