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The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC

  1. Author:
    Davis, C. A.
    Parniak, M. A.
    Hughes, S. H.

  2. Author Address

    [Hughes, SH] NCI, HIV Drug Resistance Program, NCI Frederick, Frederick, MD 21702 USA. [Parniak, MA] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA 15219 USA.;Hughes, SH (reprint author), NCI, HIV Drug Resistance Program, NCI Frederick, POB B,Bldg 539,Room 130A, Frederick, MD 21702 USA;hughesst@mail.nih.gov
    1. Year: 2011
    2. Date: Oct
  2. Journal: Virology
    1. 419
    2. 2
    3. Pages: 64-71
  4. Type of Article: Article
  5. ISSN: 0042-6822
  1. Abstract:

    It was recently proposed that HIV RT mutations that decrease RNase H activity increase zidovudine (AZT) resistance by delaying the degradation of the RNA template, allowing more time for AZTMP excision from the 3' end of the viral DNA. This predicts that suboptimal concentrations of an RNase H Inhibitor (RNHI), which would decrease RNaseH activity, would decrease AZT susceptibility. Conversely, a suboptimal concentration of a nonnucleoside RT inhibitor (NNRTI) would decrease polymerase activity and increase AZT susceptibility. We determined the effect of several RNHIs and an NNRTI (nevirapine) on AZT and lamivudine (3TC) susceptibility with vectors that replicate using WT or AZT resistant RTs. Susceptibility to 3TC, which is not readily excised, did not change significantly. Nevirapine, and most RNHIs tested, had only small effects on the susceptibility of either HIV vector to AZT and 3TC. One RNHI, F0444-0019, increased the IC(50) for AZT for either vector by similar to 5-fold, which may be a concern. Published by Elsevier Inc.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.virol.2011.08.010
  3. View record in Web of Science®
  4. WOS: 000295422500002

Library Notes

  1. Fiscal Year: FY2011-2012
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