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KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection

  1. Author:
    al Basatena, N. K. S.
    MacNamara, A.
    Vine, A. M.
    Thio, C. L.
    Astemborski, J.
    Usuku, K.
    Osame, M.
    Kirk, G. D.
    Donfield, S. M.
    Goedert, J. J.
    Bangham, C. R. M.
    Carrington, M.
    Khakoo, S. I.
    Asquith, B.

  2. Author Address

    [al Basatena, NKS; MacNamara, A; Vine, AM; Bangham, CRM; Khakoo, SI; Asquith, B] Univ London Imperial Coll Sci Technol & Med, London, England. [Thio, CL; Astemborski, J; Kirk, GD] Johns Hopkins Univ, Baltimore, MD USA. [Usuku, K] Kumamoto Univ, Kumamoto, Japan. [Osame, M] Kagoshima Univ, Kagoshima 890, Japan. [Donfield, SM] Rho, Chapel Hill, NC USA. [Goedert, JJ] NCI, Rockville, MD USA. [Carrington, M] SAIC Frederick Inc, NCI Frederick, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA. [Carrington, M] MIT, Ragon Inst MGH, Boston, MA USA. [Carrington, M] Harvard Univ, Boston, MA 02115 USA.;al Basatena, NKS (reprint author), Univ London Imperial Coll Sci Technol & Med, London, England;b.asquith@ic.ac.uk
    1. Year: 2011
    2. Date: Oct
  2. Journal: Plos Pathogens
    1. 7
    2. 10
    3. Pages: 12
  4. Type of Article: Article
  5. Article Number: e1002270
  6. ISSN: 1553-7366
  1. Abstract:

    Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.

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External Sources

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  2. DOI: 10.1371/journal.ppat.1002270
  3. View record in Web of Science®
  4. WOS: 000296734300006

Library Notes

  1. Fiscal Year: FY2011-2012
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