Skip NavigationSkip to Content
Return Return to Search Results

Fifty Years of Diazeniumdiolate Research. From Laboratory Curiosity to Broad-Spectrum Biomedical Advances

  1. Author:
    Keefer, L. K.

  2. Author Address

    NCI, Chem Sect, Comparat Carcinogenesis Lab, Frederick, MD 21702 USA.;Keefer, LK (reprint author), NCI, Chem Sect, Comparat Carcinogenesis Lab, Frederick, MD 21702 USA;keeferl@mail.nih.gov
    1. Year: 2011
    2. Date: Nov
  2. Journal: Acs Chemical Biology
    1. 6
    2. 11
    3. Pages: 1147-1155
  4. Type of Article: Review
  5. ISSN: 1554-8929
  1. Abstract:

    Here I show that a "pure" research project, seemingly totally lacking in practical application when it was first published, can years later spark a whole new scientific field with the potential to revolutionize clinical practice. A 1961 publication describing adducts of nitric oxide (NO) with certain nucleophiles attracted little notice at the time, but later work showing that the adducts could be hydrolyzed to regenerate the NO in bioactive form has provided the foundation for a host of biomedical applications Crucial to the discovery of widely used tools for studying NO'S chemical biology as well as for the design of a variety of promising therapeutic advances has been the increasingly detailed understanding of the physicochemical properties of these "diazeniumdiolates" (also known as NONOates).

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1021/cb200274r
  3. View record in Web of Science®
  4. WOS: 000297038800001

Library Notes

  1. Fiscal Year: FY2011-2012
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel