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STATE-OF-THE-ART THERAPEUTIC MEDICAL COUNTERMEASURES FOR VIRAL THREAT AGENTS

  1. Author:
    Sampath, A.
    Metz, M.
    Stundick, M.
    Larsen, J. C.

  2. Author Address

    [Metz, Matthew; Stundick, Melissa; Larsen, Joseph C.] Dept Hlth & Human Serv, Off Assistant Secretary Preparedness & Response, BARDA, BSA Program,Div CBRN Med Countermeasures, Washington, DC USA. [Sampath, Aruna] Sci Applicat Int Corp, Frederick, MD USA.;Larsen, JC (reprint author), US Dept HHS, Biomed Adv Res Dev Author, Div CBRN Med Countermeasures, Broad Spectrum Antimicrobials BSA Program, Washington, DC 20201 USA;Joseph.Larsen@hhs.gov
    1. Year: 2011
    2. Date: Dec
  2. Journal: Biosecurity and Bioterrorism-Biodefense Strategy Practice and Science
    1. 9
    2. 4
    3. Pages: 351-360
  4. Type of Article: Article
  5. ISSN: 1538-7135
  1. Abstract:

    In recent years, there has been an increase in the perceived threat of biological agents being used against civilian populations. This has prompted an urgent need for the development and procurement of medical countermeasures (MCMs) against highly pathogenic viruses that can prevent morbidity and mortality from infections caused by these agents. To date, antiviral drug development has been largely focused on clinically prevalent chronic infections due to their commercial viability. This has left a huge gap in the drug development path for acute infections of biodefense importance. In this review, we discuss the antiviral research and development initiatives focusing specifically on pox-viruses, filoviruses, and equine encephalitis viruses (EEV). We discuss the benefits and technical challenges in the current development strategies and the hurdles in the licensure path for MCMs against these highly pathogenic viruses under the FDA Animal Rule, and we provide recommendations for the path forward.

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External Sources

  1. View Full Text
  2. DOI: 10.1089/bsp.2011.0047
  3. View record in Web of Science®
  4. WOS: 000297911800004

Library Notes

  1. Fiscal Year: FY2011-2012
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