Skip NavigationSkip to Content
Return Return to Search Results

IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8(+) T effector memory population in peripheral blood

  1. Author:
    Sneller, M. C.
    Kopp, W. C.
    Engelke, K. J.
    Yovandich, J. L.
    Creekmore, S. P.
    Waldmann, T. A.
    Lane, H. C.

  2. Author Address

    [Sneller, Michael C.; Lane, H. Clifford] NIAID, Immunoregulat Lab, NIH, NCI, Bethesda, MD 20892 USA. [Kopp, William C.] SAIC Frederick Inc, Appl Dev Res Directorate, Frederick, MD USA. [Engelke, Kory J.] Avanza Labs, Gaithersburg, MD USA. [Yovandich, Jason L.; Creekmore, Stephen P.] NCI Frederick, Biol Resources Branch, Dev Therapeut Program, Frederick, MD USA. [Waldmann., Thomas A.] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA.;Sneller, MC (reprint author), NIAID, Immunoregulat Lab, NIH, NCI, 10 Ctr Dr,MSC 1763, Bethesda, MD 20892 USA;msneller@niaid.nih.gov
    1. Year: 2011
    2. Date: Dec
  2. Journal: Blood
    1. 118
    2. 26
    3. Pages: 6845-6848
  4. Type of Article: Article
  5. ISSN: 0006-4971
  1. Abstract:

    IL-15 promotes activation and maintenance of natural killer (NK) and CD8(+) T effector memory (T(EM)) cells, making it a potential immunotherapeutic agent for the treatment of cancer and immunodeficiency states. Here we report the immunologic effects of 3 different IL-15 dosing strategies in Rhesus macaques. IL-15 at a dose of 20 mu g/kg/d administered by continuous intravenous infusion for 10 days resulted in a massive (100-fold) expansion of CD8(+) T(EM) cells in the peripheral blood. In contrast, the administration of 20-40 mu g/kg/d of IL-15 by subcutaneous injection resulted in a more modest (10-fold) expansion of CD8(+) T(EM) cells. NK expansion was similar in both the continuous intravenous and daily subcutaneous treatment groups. The observation that IL-15 administered by continuous intravenous infusion is able to induce markedly greater expansions of CD8(+) T(EM) cells than the same dose administered by other routes may have important implications for clinical development of this cytokine. (Blood.2011;118(26):6845-6848)

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1182/blood-2011-09-377804
  3. View record in Web of Science®
  4. WOS: 000298401000021

Library Notes

  1. Fiscal Year: FY2011-2012
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel