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Informatics and standards for nanomedicine technology

  1. Author:
    Thomas, D. G.
    Klaessig, F.
    Harper, S. L.
    Fritts, M.
    Hoover, M. D.
    Gaheen, S.
    Stokes, T. H.
    Reznik-Zellen, R.
    Freund, E. T.
    Klemm, J. D.
    Paik, D. S.
    Baker, N. A.

  2. Author Address

    [Thomas, Dennis G.; Baker, Nathan A.] Pacific NW Natl Lab, Knowledge Discovery & Informat Grp, Richland, WA 99352 USA. [Klaessig, Fred] Penn Bio Nano Syst LLC, Doylestown, PA USA. [Harper, Stacey L.] Oregon State Univ, Sch Chem Biol & Environm Engn, Corvallis, OR 97331 USA. [Fritts, Martin] NCI, SAIC Frederick, Frederick, MD 21701 USA. [Hoover, Mark D.] NIOSH, Morgantown, WV USA. [Gaheen, Sharon] SAIC, Hlth Solut Business Unit, Rockville, MD USA. [Stokes, Todd H.] Emory Univ, Dept Biomed Engn, Atlanta, GA 30322 USA. [Stokes, Todd H.] Georgia Tech, Atlanta, GA USA. [Reznik-Zellen, Rebecca] Univ Massachusetts, Ctr Hierarch Mfg, Amherst, MA 01003 USA. [Freund, Elaine T.] 3rd Millenium Inc, Waltham, MA USA. [Klemm, Juli D.] NCI, Ctr Biomed Informat & Informat Technol, Bethesda, MD 20892 USA. [Paik, David S.] Stanford Univ, Radiol Sci Lab, Stanford, CA 94305 USA.;Baker, NA (reprint author), Pacific NW Natl Lab, Knowledge Discovery & Informat Grp, Richland, WA 99352 USA;nathan.baker@pnl.gov
    1. Year: 2011
    2. Date: Sep-Oct
  2. Journal: Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
    1. 3
    2. 5
    3. Pages: 511-532
  4. Type of Article: Review
  5. ISSN: 1939-5116
  1. Abstract:

    There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In this work, we have reviewed three areas of nanomedicine informatics: information resources; taxonomies, controlled vocabularies, and ontologies; and information standards. Informatics methods and standards in each of these areas are critical for enabling collaboration; data sharing; unambiguous representation and interpretation of data; semantic (meaningful) search and integration of data; and for ensuring data quality, reliability, and reproducibility. In particular, we have considered four types of information standards in this article, which are standard characterization protocols, common terminology standards, minimum information standards, and standard data communication (exchange) formats. Currently, because of gaps and ambiguities in the data, it is also difficult to apply computational methods and machine learning techniques to analyze, interpret, and recognize patterns in data that are high dimensional in nature, and also to relate variations in nanomaterial properties to variations in their chemical composition, synthesis, characterization protocols, and so on. Progress toward resolving the issues of information management in nanomedicine using informatics methods and standards discussed in this article will be essential to the rapidly growing field of nanomedicine informatics. (C) 2011 JohnWiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2011 3 511-532 DOI: 10.1002/wnan.152

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External Sources

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  2. DOI: 10.1002/wnan.152
  3. View record in Web of Science®
  4. WOS: 000298258800007

Library Notes

  1. Fiscal Year: FY2011-2012
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