Skip NavigationSkip to Content
Return Return to Search Results

Annexin 1 Released by Necrotic Human Glioblastoma Cells Stimulates Tumor Cell Growth through the Formyl Peptide Receptor 1

  1. Author:
    Yang, Y.
    Liu, Y.
    Yao, X. H.
    Ping, Y. F.
    Jiang, T.
    Liu, Q.
    Xu, S. L.
    Huang, J.
    Mou, H. W.
    Gong, W. H.
    Chen, K. Q.
    Bian, X. W.
    Wang, J. M.

  2. Author Address

    [Yang, Yan; Liu, Ying; Chen, Keqiang; Wang, Ji Ming] NCI, LMI, CIP, CCR, Frederick, MD 21702 USA. [Yang, Yan] Ocean Univ China, Coll Marine Life Sci, Qingdao, Peoples R China. [Yao, Xiaohong; Ping, Yifang; Liu, Qin; Xu, Senlin; Bian, Xiuwu] Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing, Peoples R China. [Yao, Xiaohong; Ping, Yifang; Liu, Qin; Xu, Senlin; Bian, Xiuwu] Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing, Peoples R China. [Jiang, Tao] Capital Med Univ, Tiantan Hosp, Dept Nerosurg, Beijing, Peoples R China. [Huang, Jian] Third Mil Med Univ, Coll High Altitude Mil Med, Dept Pathophysiol, Chongqing, Peoples R China. [Mou, Haiwei] Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China. [Gong, Wanghua; Wang, Ji Ming] Sci Applicat Int Corp SAIC Frederick, Basic Res Program, Frederick, MD USA.;Wang, JM (reprint author), NCI, LMI, CIP, CCR, Bldg 560,Room 31-76, Frederick, MD 21702 USA;wangji@mail.nih.gov
    1. Year: 2011
    2. Date: Sep
  2. Journal: American Journal of Pathology
    1. 179
    2. 3
    3. Pages: 1504-1512
  4. Type of Article: Article
  5. ISSN: 0002-9440
  1. Abstract:

    Highly malignant human gliomas overexpress the G-protein-coupled chemoattractant receptor forinyl peptide receptor (FPR1), which promotes tumor progression when activated. Our previous studies demonstrated that necrotic glioblastoma cells release chemotactic agonist(s) that activate FPR1 on viable tumor cells. In the present study, we identified an FPR1 agonist released by necrotic human glioblastoma cells. Necrotic tumor cell supernatant (NecSup) contained Annexin 1 (Anx A1), a chemotatic polypeptide agonist for FPR1 Immunoabsorption of Anx A1 with a specific antibody markedly reduced the chemotactic activity of NecSup for tumor cells and diminished its capacity to promote tumor cell growth, invasion, and colony formation on soft agar. In addition, Anx A1 was present in tumor xenografts formed by human glioblastoma cells in nude mice. Anx A1 knockdown significantly reduced the tumorigenicity of glioblastoma cells in nude mice, but FPR1/Anx A1 double knockdown diminished tumor growth even further. The clinical relevance of Anx A1 in gliomas was supported by the observation that Anx A1 was more highly expressed in poorly differentiated human primary gliomas compared with lower grade tumors. Our study implicates Anx A1 as a major component in necrotic tumor cell-derived stimulants of the growth of glioblastoma via the activation of FPR1. (Am J Pathol 2011, 179:1504-1512; DOI: 10.1016/j.ajpath.2011.05.059)

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.ajpath.2011.05.059
  3. View record in Web of Science®
  4. WOS: 000298307300043

Library Notes

  1. Fiscal Year: FY2011-2012
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel