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Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma

  1. Author:
    Bassig, B. A.
    Zheng, T. Z.
    Zhang, Y. W.
    Berndt, S. I.
    Holford, T. R.
    Hosgood, H. D.
    Hu, W.
    Leaderer, B.
    Yeager, M.
    Menashe, I.
    Boyle, P.
    Xu, J.
    Zou, K. Y.
    Zhu, Y.
    Chanock, S.
    Rothman, N.
    Lan, Q.

  2. Author Address

    [Bassig, Bryan A.; Berndt, Sonja I.; Hosgood, H. Dean, III; Hu, Wei; Xu, Jun; Rothman, Nathaniel; Lan, Qing] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA. [Zheng, Tongzhang; Zhang, Yawei; Leaderer, Brian; Zhu, Yong] Yale Univ, Sch Publ Hlth, Div Environm Hlth Sci, New Haven, CT USA. [Holford, Theodore R.] Yale Univ, Sch Publ Hlth, Div Biostat, New Haven, CT USA. [Yeager, Meredith; Chanock, Stephen] NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA. [Menashe, Idan] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA. [Boyle, Peter] Int Prevent Res Inst, Lyon, France. [Zou, Kaiyong] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT USA.;Bassig, BA (reprint author), NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, 6120 Execut Blvd,EPS 8010,MCS 7240, Bethesda, MD 20892 USA;bryan.bassig@yale.edu
    1. Year: 2012
    2. Date: Mar
  2. Journal: Environmental and Molecular Mutagenesis
    1. 53
    2. 2
    3. Pages: 145-151
  4. Type of Article: Article
  5. ISSN: 0893-6692
  1. Abstract:

    The complement system plays an important role in inflammatory and immune responses, and recent evidence has suggested that it may also play a role in lymphomagenesis. We evaluated the association between genetic variation in complement system genes and risk of non-Hodgkin lymphoma (NHL) in a population-based casecontrol study conducted among women in Connecticut. Tag SNPs in 30 complement genes were genotyped in 432 Caucasian incident cases and 494 frequency-matched controls. A gene-based analysis that adjusted for the number of tag SNPs genotyped in each gene showed a significant association with NHL overall (P = 0.04) as well as with diffuse large B-cell lymphoma (DLBCL) (P = 0.01) for the C1RL gene. A SNP-based analysis showed that a C>T base substitution for C1RL rs3813729 (odds ratio (OR)CT = 0.60, 95% confidence interval (CI) = 0.420.87, Ptrend = 0.0062) was associated with a decreased risk of overall NHL, as well as for DLBCL (ORCT = 0.39, 95% CI = 0.200.73; Ptrend = 0.0034). Additionally, SNPs (C2 rs497309, A>C and C3 rs344550, G>C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and C1QG was associated with CLL/SLL, but these results were based on a limited number of cases. Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings. Environ. Mol. Mutagen., 2012. Published 2011 Wiley-Liss, Inc.

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External Sources

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  2. DOI: 10.1002/em.21675
  3. View record in Web of Science®
  4. WOS: 000299831600007

Library Notes

  1. Fiscal Year: FY2011-2012
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