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The role of upregulated miRNAs and the identification of novel mRNA targets in prostatospheres

  1. Author:
    Cabarcas, S. M.
    Thomas, S.
    Zhang, X. H.
    Cherry, J. M.
    Sebastian, T.
    Yerramilli, S.
    Lader, E.
    Farrar, W. L.
    Hurt, E. M.

  2. Author Address

    [Cabarcas, Stephanie M.; Farrar, William L.; Hurt, Elaine M.] NCI, Canc Stem Cell Sect, Lab Canc Prevent, Ctr Canc Res, Frederick, MD 21701 USA. [Thomas, Suneetha; Zhang, Xiaohu] NCI, Canc Stem Cell Sect, Lab Canc Prevent, SAIC Frederick Inc, Frederick, MD 21701 USA. [Cherry, James M.; Sebastian, Thomas; Yerramilli, Subu; Lader, Eric] Qiagen Sci, Res & Dev, Frederick, MD USA.;Hurt, EM (reprint author), MedImmune, 1 MedImmune Way, Gaithersburg, MD USA;Stephanie.Cabarcas@nih.gov sunithathomas2000@yahoo.com Xiaohu.Zhang@nih.gov Jim.Cherry@nih.gov tsebastian70@gmail.com Subu.yerramilli@qiagen.com Eric.Lader@qiagen.com farrarw@nih.gov HurtE@MedImmune.com
    1. Year: 2012
    2. Date: Feb
  2. Journal: Genomics
    1. 99
    2. 2
    3. Pages: 108-117
  4. Type of Article: Article
  5. ISSN: 0888-7543
  1. Abstract:

    TICs are characterized by their ability to self-renew, differentiate and initiate tumor formation. miRNAs are small noncoding RNAs that bind to mRNAs resulting in regulation of gene expression and biological functions. The role of miRNAs and TICs in cancer progression led us to hypothesize that miRNAs may regulate genes involved in TIC maintenance. Using whole genome miRNA and mRNA expression profiling of TICs from primary prostate cancer cells, we identified a set of up-regulated miRNAs and a set of genes down-regulated in PSs. Inhibition of these miRNAs results in a decrease of prostatosphere formation and an increase in target gene expression. This study uses genome-wide miRNA profiling to analyze expression in TICs. We connect aberrant miRNA expression and deregulated gene expression in TICs. These findings can contribute to a better understanding of the molecular mechanisms governing TIC development/maintenance and the role that miRNAs have in the fundamental biology of TICs. (C) 2011 Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.ygeno.2011.11.007
  3. View record in Web of Science®
  4. WOS: 000300277300007

Library Notes

  1. Fiscal Year: FY2011-2012
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