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CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells

  1. Author:
    Ko, C. Y.
    Chang, L. H.
    Lee, Y. C.
    Sterneck, E.
    Cheng, C. P.
    Chen, S. H.
    Huang, A. M.
    Tseng, J. T.
    Wang, J. M.

  2. Author Address

    [Wang, Ju-Ming] Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Inst Biosignal Transduct, Tainan 70101, Taiwan. [Ko, Chiung-Yuan; Wang, Ju-Ming] Natl Cheng Kung Univ, Ctr Gene Regulat & Signal Transduct Res, Tainan 70101, Taiwan. [Chang, Ling-Hua] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan. [Lee, Yi-Chao] Natl Cheng Kung Univ, Dept Pharmacol, Tainan 70101, Taiwan. [Sterneck, Esta] NCI, Ctr Canc Res, Frederick, MD 21701 USA. [Cheng, Chun-Pei; Tseng, Joseph T.; Wang, Ju-Ming] Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Inst Bioinformat, Tainan 70101, Taiwan. [Chen, Shun-Hua] Natl Cheng Kung Univ, Dept Microbiol & Immunol, Tainan 70101, Taiwan. [Huang, A-Mei] Kaohsiung Med Univ, Dept Biochem, Kaohsiung, Taiwan.;Wang, JM (reprint author), Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Inst Biosignal Transduct, Tainan 70101, Taiwan;yumingw@mail.ncku.edu.tw
    1. Year: 2012
    2. Date: Feb
  2. Journal: Neurobiology of Aging
    1. 33
    2. 2
  4. Type of Article: Article
  5. Article Number: 422.e11
  6. ISSN: 0197-4580
  1. Abstract:

    The CCAAT/enhancer binding protein delta (CEBPD, C/EBP delta, NF-IL6 beta) is induced in many inflammation-related diseases, suggesting that CEBPD and its downstream targets may play central roles in these conditions. Neuropathological studies show that a neuroinflammatory response parallels the early stages of Alzheimer's disease (AD). However, the precise mechanistic correlation between inflammation and AD pathogenesis remains unclear. CEBPD is upregulated in the astrocytes of AD patients. Therefore, we asked if activation of astrocytic CEBPD could contribute to AD pathogenesis. In this report, a novel role of CEBPD in attenuating macrophage-mediated phagocytosis of damaged neuron cells was found. By global gene expression profiling, we identified the inflammatory marker pentraxin-3 (PTX3, TNFAIP5, TSG-14) as a CEBPD target in astrocytes. Furthermore, we demonstrate that PTX3 participates in the attenuation of macrophage-mediated phagocytosis of damaged neuron cells. This study provides the first demonstration of a role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of AD pathogenesis. (C) 2012 Elsevier Inc. All rights reserved.

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  2. DOI: 10.1016/j.neurobiolaging.2010.09.017
  3. View record in Web of Science®
  4. WOS: 000298171800025

Library Notes

  1. Fiscal Year: FY2011-2012
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