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A new anti-tubulin agent containing the benzo

  1. Author:
    Pinney, K. G.
    Bounds, A. D.
    Dingeman, K. M.
    Mocharla, V. P.
    Pettit, G. R.
    Bai, R.
    Hamel, E.

  2. Author Address

    Pinney KG Baylor Univ, Dept Chem POB 97348 Waco, TX 76798 USA Baylor Univ, Dept Chem Waco, TX 76798 USA Arizona State Univ, Canc Res Inst Tempe, AZ 85287 USA Arizona State Univ, Dept Chem Tempe, AZ 85287 USA NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Proram,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr Ft Detrick, MD 21702 USA
    1. Year: 1999
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 9
    2. 8
    3. Pages: 1081-1086
  4. Type of Article: Article
  1. Abstract:

    A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6-methoxybenzo[b ]thio 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 33]

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