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Yaoundamines a and B, New Antimalarial Naphthylisoquinoline Alkaloids From Ancistrocladus Korupensis

  1. Author:
    Hallock, Y. F.
    Cardellina, J. H.
    Schaffer, M.
    Stahl, M.
    Bringmann, G.
    Francois, G.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI DIV CANC TREATMENT DIAG & CTR DEV THERAPEUT PROGRAM LAB DRUG DISCOVERY RES & DEV BLDG 1052 FREDERICK, MD 21702 USA NCI DIV CANC TREATMENT DIAG & CTR DEV THERAPEUT PROGRAM LAB DRUG DISCOVERY RES & DEV FREDERICK, MD 21702 USA UNIV WURZBURG INST ORGAN CHEM D-97074 WURZBURG GERMANY INST TROP MED PRINCE LEOPOLD B-2000 ANTWERP BELGIUM
    1. Year: 1997
  2. Journal: Tetrahedron
    1. 53
    2. 24
    3. Pages: 8121-8128
  4. Type of Article: Article
  1. Abstract:

    New monomeric naphthylisoquinoline alkaloids, yaoundamines A and B, were isolated from Ancistrocladus korupensis and their structures were determined by extensive chemical and spectroscopic analyses. The absolute configuration at C3 was established by chemical degradation, while the axial chirality was deduced by comparison of experimental and calculated CD spectra. Yaoundamine B has an unprecedented glycosylated naphthylisoquinoline structure. Yaoundamines A and B are active in vitro against the malaria parasite Plasmodium falciparum. . [References: 19]

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