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Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission

  1. Author:
    Lockett, S. F.
    Alonso, A.
    Wyld, R.
    Martin, M. P.
    Robertson, J. R.
    Gore, S. M.
    Leen, C. L. S.
    Brettle, R. P.
    Yirrell, D. L.
    Carrington, M.
    Brown, A. J. L.

  2. Author Address

    Brown AJL Univ Edinburgh, Inst Cell Anim & Populat Biol, Ctr HIV Res Waddington Bldg,W Mains Rd Edinburgh EH9 3JN Midlothian Scotland Univ Edinburgh, Inst Cell Anim & Populat Biol, Ctr HIV Res Edinburgh EH9 3JN Midlothian Scotland Univ Edinburgh, Muirhouse Med Grp, Edinburgh Drug Addict Study Edinburgh EH9 3JN Midlothian Scotland Univ Edinburgh, Dept Gen Practice Edinburgh EH9 3JN Midlothian Scotland City Hosp Edinburgh, Reg Infect Dis Unit Edinburgh EH10 5SB Midlothian Scotland Inst Publ Hlth, MRC, Biostat Unit Cambridge England NCI, Intramural Res Support Program, Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA
    1. Year: 1999
  2. Journal: Journal of Infectious Diseases
    1. 180
    2. 3
    3. Pages: 614-620
  4. Type of Article: Article
  1. Abstract:

    To assess the effect of mutations at the CCR-2 and CCR-5 loci on heterosexual human immunodeficiency virus (HIV) transmission, 144 persons heterosexually exposed to HIV (infected and uninfected [EU]) and 57 HIV-positive index partners were genotyped, A significantly higher frequency of 64I heterozygotes at CCR-2 was observed in HIV-positive than in EU women (P = .02, relative risk = 1.6). The allele frequency of 64I in women was 8% in HIV-positive contacts and 1% in EUs (P <.02), At CCR-5, no difference in the frequency of Delta 32 was seen between groups, and the CCR-5 genotypes did not differ in accumulated "at-risk" exposure in EUs, Combining the analysis of the Delta 32 and 64I mutations in index partners suggested an additive effect on transmission (P =.10). Thus heterozygosity for 64I at CCR-2 acts as a risk factor for HIV infection of women after heterosexual contact but heterozygosity for Delta 32 at CCR-5 has no detectable effect. [References: 39]

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