Skip NavigationSkip to Content
Return Return to Search Results

HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

  1. Author:
    Maldarelli, F.
    Wu, X.
    Su, L.
    Simonetti, F. R.
    Shao, W.
    Hill, S.
    Spindler, J.
    Ferris, A. L.
    Mellors, J. W.
    Kearney, M. F.
    Coffin, J. M.
    Hughes, S. H.

  2. Author Address

    HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA. Leidos Biomedical Research, Frederick, MD 21702, USA. HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA. Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, 20122 Milan, Italy. Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA. HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA. hughesst@mail.nih.gov.
    1. Year: 2014
    2. Date: 11-Jul
    3. Epub Date: 6/28/2014
  2. Journal: Science
    1. 345
    2. 6193
    3. Pages: 179-83
  4. Type of Article: Article
  5. ISSN: 1095-9203 (Electronic) 0036-8075 (Linking)
  1. Abstract:

    The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted for many years. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1126/science.1254194
  3. PMID: 24968937

Library Notes

  1. Fiscal Year: FY2013-2014
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel