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Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin

  1. Author:
    Lee-Huang, S.
    Huang, P. L.
    Sun, Y. T.
    Kung, H. F.
    Blithe, D. L.
    Chen, H. C.

  2. Author Address

    Chen HC NYU, Sch Med, Dept Biochem New York, NY 10016 USA NYU, Sch Med, Dept Biochem New York, NY 10016 USA Massachusetts Gen Hosp, Dept Med Boston, MA 02114 USA Harvard Univ, Sch Med Boston, MA 02114 USA Harvard Community Hlth Plan Boston, MA 02114 USA NCI, Frederick Canc Res & Dev Ctr, Lab Biochem Physiol Frederick, MD 21701 USA NICHHD, Contracept & Reprod Hlth Branch, NIH Bethesda, MD 20892 USA NICHHD, Endocrinol & Reprod Res Branch, NIH Bethesda, MD 20892 USA
    1. Year: 1999
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 96
    2. 6
    3. Pages: 2678-2681
  4. Type of Article: Article
  1. Abstract:

    Human chorionic gonadotropin (hCG) preparations contain activity against HIT: type 1 (HIV-1). However, there has been controversy about whether some biological activities of hCG beta-subunit (hCG beta) preparations are caused by the beta-subunit itself or other proteins present in the preparations, We report here the purification, characterization, and identification of three enzymes with anti-HIV activity present in the beta-core fraction of hCG beta prepared from the urine of pregnant women. The N-terminal amino acid sequence of one protein is identical to human urinary lysozyme C, and those of the other two are identical to human RNase A and urinary RNase U. We thus refer to these proteins as AVL (antiviral lysozyme) and AVR (antiviral RNases). In addition to HIV-1 inhibition, AVL is capable of lysing Micrococcus lysodeikticus. AVR digests a variety of RNA substrates, including RNA from HIV-1-infected cells. We also find that lysozyme from chicken egg white, human milk and human neutrophils and RNase A from bovine pancreas possess activity against HIV-I. These findings may offer additional strategies for the treatment of HIV-1 infection. [References: 21]

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